ChemInform Abstract: Unexpected Regioselectivity in Cycloisomerization of 2‐Alkynyl‐3‐nitrothiophenes.

Abstract

Unexpected Regioselectivity in Cycloisomerization of 2-Alkynyl-3-nitrothiophenes. -Optimized reaction conditions using AuCl3 or silver trifluoroacetate as the catalyst are developed for the cycloisomerization of 2-alkynyl-3-nitrothiophenes (I) or the corresponding isomers (III) to give thienoisoxazoles (II) and (IV) in moderate to good yields. -(CIKOTIENE*, I.; SAZINAS, R.; MAZEIKAITE, R.; LABANAUSKAS, L.; Synlett 2010, 20, 3027-3030, http://dx.doi.org/10.1055/s-0030-1259053 ; Dep. Org. Chem., Vilnius Univ., Vilnius 03225, Lithuania; Eng.) -Mais 17-134