ChemInform Abstract: Use of Non‐Conventional Reaction Media — A Green Approach

Rajni, Ratti

doi:10.1002/chin.201537262

Cited by 1 publication

(1 citation statement)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In light of the need for greater sustainability in chemical processes, , the concept of green chemistry has not left the Suzuki–Miyaura reaction untouched. − In attempts to make the Suzuki–Miyaura reaction more environmentally friendly, , the use of alternative solvents has become increasingly important. − One of the most abundant and least toxic reaction media is water, and thus many catalyst systems have been developed to enable efficient Suzuki–Miyaura cross-couplings in this medium. − Typically, to not sacrifice the ability to efficiently couple the less expensive but also less reactive aryl chlorides, organometallic palladium complexes have to be employed.…”

Section: Introductionmentioning

confidence: 99%

Cyclometalated Palladium NHC Complexes Bearing PEG Chains for Suzuki–Miyaura Cross-Coupling in Water

2018

View full text Add to dashboard Cite

We present the synthesis and characterization of four new polyethylene glycol (PEG) substituted palladium complexes bearing a cyclometalated 2-phenylimidazole ligand and an N-heterocyclic carbene (NHC) ligand. A solid-state structure reveals the chelating binding mode and the coiling of the PEG chain in the auxiliary ligand. The PEG substitution significantly increased the solubility of the complexes in several solvents, enabling the efficient Suzuki−Miyaura crosscoupling reaction of aryl chlorides in an aqueous medium. Under optimized reaction conditions, sterically demanding biphenyl compounds with up to three ortho substituents were accessible in good to excellent yields.

show abstract