ChemInform Abstract: (Z)‐Selective Synthesis of o‐Bromoacetophenone N‐Tosylhydrazones and Formation of 3‐Methylindazoles in Aqueous Ethanol.

Abstract

Z)-Selective Synthesis of o-Bromoacetophenone N-Tosylhydrazones and Formation of 3-Methylindazoles in Aqueous Ethanol. -A practical method for the synthesis of precursors (III) is described. Optimized conditions allow the cyclization of bromides (IIIa)-(IIIc) to 3-methylindazoles. -(KYLMAELAE, T.; UDD, S.; TOIS*, J.; FRANZEN, R.; Tetrahedron Lett. 51 (2010) 28, 3613-3615,