Cheminformatics based selection and cytotoxic effects of herbal extracts

Sardari, Soroush; Shokrgozar, Mohammad Ali; Ghavami, Ghazaleh

doi:10.1016/j.tiv.2009.07.011

Cited by 30 publications

(22 citation statements)

References 28 publications

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“…The plates were incubated at 35°C for 24 h and after that, the diameter of the zone of inhibition of the bacterial growth around the discs were determined. Naringenin (5) Luteolin (6) Quercetin (7) Vitexin (R= glucose) (8) Quercetin 3-O-β-glucoside (R=glucose) (9) Rutin (10) (Sardari et al, 2009), some of them from the Moraceae family. It is already reported that the cytotoxicity potential of compounds varies with the type of cell line and the method employed to evaluate it (Nogueira et al 2011), also with the type of substance which is investigated and its time of exposition (Van de Sandt, 1992).…”

Section: Antibacterial Assaymentioning

confidence: 99%

Evaluation of cytotoxicity, anti-herpes simplex virus type 1 (HSV-1) and antibacterial activities of Ficus vasta and phytoconstituents

Rashed

Ono²

2013

Int Curr Pharm J

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This study deals with the evaluation of in vitro cytotoxicity of the methanol 80% extract of Ficus vasta aerial parts in Vero cells, anti-HSV-1 and antibacterial activities and the determination of the phytochemical content of the F. vasta methanol extract. The extract was tested for its cytotoxicity in Vero cells and for anti-HSV-1 and against bacterial strains as S. aureus, S. epidermidis, E. coli and P. aeruginosa and also phytochemical constituents were detected. The results showed that this extract presented a CC50 value of 389 µg/mL, an intermediate value taking into account other researchers reported for some Moraceae species. Regarding the other biological activities, antiviral effect was not demonstrated by a HSV-1 challenge dilution of 100x tissue culture infective dose 50% (TCID50) and also by the disk-diffusion method at the higher non-toxic concentration of the extract (119 µg/mL). Phytochemical analysis of the methanol extract proved the presence of carbohydrates, tannins, flavonoids, coumarins, alkaloids and triterpenes. Chromatographic separation of the methanol extract resulted in the isolation and identification of ?-sitosterol, stigmasterol, lupeol, ursolic acid, naringenin, luteolin, quercetin, vitexin, quercetin 3-O-?-glucoside and rutin. The results indicated that F. vasta aerial parts methanol extract is potential candidate for experiments of biological activity screening that are not anti-HSV-1 or antibacterial against the strains evaluated in this study, to be carried on in the future.DOI: http://dx.doi.org/10.3329/icpj.v3i1.17295 International Current Pharmaceutical Journal, December 2013, 3(1): 211-218

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Section: Antibacterial Assaymentioning

confidence: 99%

Evaluation of cytotoxicity, anti-herpes simplex virus type 1 (HSV-1) and antibacterial activities of Ficus vasta and phytoconstituents

Rashed

Ono²

2013

Int Curr Pharm J

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“…Therefore, the anti-depressant properties of R. ribes could be due to the anti-cholinesterase activity shown in this study. Other findings indicated that some components of R. ribes extract demonstrated selective cytotoxic activity on cancerous cell lines (23). The stem and root of R. ribes exhibited an antioxidant activity (24), but this plant did not have any inhibitory effect on the alpha glucosidase or the pancreatic lipase activity (1417).…”

Section: Discussionmentioning

confidence: 99%

Screening the methanol extracts of some Iranian plants for tyrosinase inhibitory activity

Gholamhoseinian

Razmi

2011

Clinical Biochemistry

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“…On the base these recent cheminformatics methodologies applied in combinational therapies, cheminformatics-based selection of candidate herbs employed as a new advance in merging cheminformatics, thorough literature handling, together with association of biologic records to search for the respected biologic property such as synergistic activity with anticancer compounds in the domain of natural products that were not explored before. Resulted investigations can play resourceful task to providence time and cost in lead identification phase for natural drug discovery process [135,136].…”

Section: Incorrect or Incomplete Assignment Of Mechanism Of Actionmentioning

confidence: 99%

Informatics of Drug Synergism in Naturally Occurring Anticancer Agents

Ghavami

Kazemali²,

Sardari³

2011

PRA

Self Cite

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Cancer is a multi-factorial disease resulting in uncontrolled division of body cells, with difficult and complex suppression. The main treatment strategy for this disease depends on killing of tumor cells that usually exist in the proximity of normal body cells. During the course of treatment, the healthy cells should not be affected by the toxic doses of the drug. Therefore, it seems that combination drug therapy is a suitable solution to address the mentioned concern. Indeed the use of multiple drugs with different actions and/or targets, in order to overcome the tumor cells, can lead to decreased drug effective dose and increased protection of normal cells against antitumor drugs. This review is focused on informatics applications in cancer combination drug therapy. At first, a brief description of recent findings on biology of resistance to cytotoxic agents is covered. Then, combinational drug therapy in cancer treatment, cheminformatics applications of synergistic compounds in cancer therapy, strategies used to overcome MDR (Multi Drug Resistance) and combinational drug therapy in cancer treatment have been discussed in the continuation. Natural compounds synergistic with anticancer agents have been reviewed in the following topics and lastly, the recent patents in the related area of combinational therapy are briefed.

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Cheminformatics based selection and cytotoxic effects of herbal extracts

Cited by 30 publications

References 28 publications

Evaluation of cytotoxicity, anti-herpes simplex virus type 1 (HSV-1) and antibacterial activities of Ficus vasta and phytoconstituents

Evaluation of cytotoxicity, anti-herpes simplex virus type 1 (HSV-1) and antibacterial activities of Ficus vasta and phytoconstituents

Screening the methanol extracts of some Iranian plants for tyrosinase inhibitory activity

Informatics of Drug Synergism in Naturally Occurring Anticancer Agents

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