Cheminformatics identification of phenolics as modulators of penicillin binding protein (PBP) 2x ofStreptococcus pneumoniaetowards interventive antibacterial therapy
Jamiu Olaseni Aribisala,
Nosipho Wendy S’thebe,
Saheed Sabiu
Abstract:Infections caused by multidrug-resistantStreptococcus pneumoniaeremain the leading cause of pneumonia-related deaths in children < 5 years globally, and mutations in penicillin-binding protein (PBP) 2x have been identified as the major cause of resistance in the organism to beta-lactams. Thus, the development of new modulators with enhanced binding of PBP2x is highly encouraged. In this study, phenolics, due to their reported antibacterial activities, were screened against the active site of PBP2x using str… Show more
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