Chemische Konstitution und pharmakologische Wirkung

Neumann, F.

doi:10.1007/978-3-642-99941-3_6

Cited by 7 publications

(4 citation statements)

References 997 publications

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“…however, the activity of norethisterone acetate after oral administration was higher order the experimental conditions used by Neumann (1968 metestrus; in the latter case, the corpora lutea are still active. As in the human after intramuscular injection (Breuer et al, 1960), norethisterone acetate is possibly transformed to estrogens in the rat when it is given orally, and thus it will stimulate prolactin release (Amenomorl et al, 1970).…”

Section: Progestinsmentioning

confidence: 80%

Progestagenic and Antigonadotrophic Activities of STS 557¹)

Stölzner¹,

Kurischko²,

Freund³

et al. 2009

Exp Clin Endocrinol Diabetes

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STS 557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4, 9-dien-3-one) was tested for progestagenic activity in rabbits and for ovulation-inhibiting activities in rabbits and rats in comparison with levonorgestrel and, in some cases, with norethisterone acetate or chlormadinone acetate. In the immature rabbit, the endometrium transformation-inducing activity of STS 557 was about 5 times higher than levonorgestrel for both oral and subcutaneous administration. The ovulation-inhibiting effect of STS 557 was 3.5 times higher than that of levonorgestrel in the rabbit after oral administration, and about 7 times higher in the rat. After subcutaneous injection, however, the antiovulatory activity of STS 557 in rats was only about 4% of that of levonorgestrel when the ED 50 were compared.

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Section: Progestinsmentioning

confidence: 80%

Progestagenic and Antigonadotrophic Activities of STS 557¹)

Stölzner¹,

Kurischko²,

Freund³

et al. 2009

Exp Clin Endocrinol Diabetes

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“…It has been shown in rat experiments that after treatment with high doses of an estrogen (150 pg dienoestroldiacetate, twice weekly) libido and fertility as well as spermatogenesis could be maintained in most of the animals by intratesticular implantation of 3 mg testosterone. Experiments by Steinberger and Steinberger (1969) and our own group (Neumann -1968), have shown that all effects induced by estrogens are abolished by adequate substitution with gonadotrophins or androgens. Figure 6 shows an example.…”

Section: Indirect Effects Of Pharmaceutical Compounds On Testes Functmentioning

confidence: 87%

“…Other progestogens do not influence testicular function, for instance: Hydroxyprogesterone caproate, norhydroxyprogesterone caproate and progesterone itself. (For rewiev see Neumann -1968).…”

Section: S Y N T H E T I C P R O G E S T O G E N Smentioning

confidence: 99%

The Influence of Pharmaceutical Compounds on Male Fertility*

Neumann¹,

Fa²,

Sh³

et al. 2009

Andrologia

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“…Results of subcutaneous applications of the test compounds were taken as parameter compared with progesterone (P-1 = 1) (Neumann, 1968).…”

Section: Vmax and Biological Activitiesmentioning

confidence: 99%

Kinetic Study of the Enzymatic Inactivation of Progestogens by Rat Liver Microsomes

Abraham¹,

Taubert²

1975

Horm Res

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The kinetics of enzymatic hydrogenation of synthetic progestogens by female rat liver microsomes with NADPH as hydrogen donor were investigated by means of an optical test. Steroids with high progestational activity (Clauberg test) showed a low hydrogenation rate (V_max). There also seemed to be a certain correlation between molecular structure and V_max. The metabolites from incubation with the progestogens were isolated from the micro-preparations, and identified by infrared spectroscopy. It was found that the hydrogenation of the olefinic and carbonylic groups involved the uptake of hydrogen from NADPH.

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Chemische Konstitution und pharmakologische Wirkung

Cited by 7 publications

References 997 publications

Progestagenic and Antigonadotrophic Activities of STS 557¹)

Progestagenic and Antigonadotrophic Activities of STS 557¹)

The Influence of Pharmaceutical Compounds on Male Fertility*

Kinetic Study of the Enzymatic Inactivation of Progestogens by Rat Liver Microsomes

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Chemische Konstitution und pharmakologische Wirkung

Cited by 7 publications

References 997 publications

Progestagenic and Antigonadotrophic Activities of STS 5571)

Progestagenic and Antigonadotrophic Activities of STS 5571)

The Influence of Pharmaceutical Compounds on Male Fertility*

Kinetic Study of the Enzymatic Inactivation of Progestogens by Rat Liver Microsomes

Contact Info

Product

Resources

About

Progestagenic and Antigonadotrophic Activities of STS 557¹)

Progestagenic and Antigonadotrophic Activities of STS 557¹)