Chemistry and Biological Activities of Caffeic Acid Derivatives from Salvia miltiorrhiza

Jiang, Ren‐Wang; Lau, Ken; Hon, Po‐Ming; Mak, Thomas C. W.; Woo, Kam-Sang; Fung, Kwok‐Pui

doi:10.2174/0929867053363397

Cited by 314 publications

(175 citation statements)

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“…As a popular traditional medicine, propolis is a rich source of caffeic acid. The active components of the propolis responsible for its clinical usages were extensively studied [8] . The Batang sample showed the presence of groups of aromatics acids, terpenes and quinoline.…”

Section: Discussionmentioning

confidence: 99%

Chemical Composition of Propolis from Different Regions in Java and their Cytotoxic Activity

Syamsudin¹,

Wiryowidagdo²,

Simanjuntak³

et al. 2009

American J. of Biochemistry and Biotechnology

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Problem statement: Propolis samples from tropical zones, such as Java (Indonesia) with its vast biodiversity, have become a subject of increasing scientific and economic attention. The association of the chemical composition of propolis from different geographic regions with cytotoxic activities lead to the identification of active principles, a fundamental tool to achieve standardization of this bee product. Approach: The purpose of this research was evaluate the quality of propolis collected at different places in Java (Indonesia) based on cytotoxic activity. The ethanolic extracts of propolis from different areas in Java were tested for cytotoxicity against tumor cell lines (T47D, MCF-7, Hela, Myeloma and Vero) using MTT assay. Propolis samples were collected from Batang (Central Java), Lawang (East Java) and Sukabumi (West Java). Results: The extract of propolis from Batang showed the most potent activity of T47D and MCF-7 with IC 50 34.67±8.3 and 37.8±2.5 µg mL −1 . The extract of propolis from Sukabumi showed the most potent activity of Hela cell with IC 50 147.34±8.9. However, all propolis extract did not show activity of myeloma and Vero cells. Conclusion: Ethanolics extract of three propolis samples from Batang (Central Java), Lawang (East Java) and Sukabumi (West Java) regions in Java were investigated using GC-MS. From 37 compounds identified, 7 among of them were found for the first time in propolis. This indicated that the secondary metabolite extract of propolis from Batang (Central Java) obtained in the study has antiproliferative activity of breast carcinoma cells (T47D and MCF-7).

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Section: Discussionmentioning

confidence: 99%

Chemical Composition of Propolis from Different Regions in Java and their Cytotoxic Activity

Syamsudin¹,

Wiryowidagdo²,

Simanjuntak³

et al. 2009

American J. of Biochemistry and Biotechnology

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“…It is mainly used in treatment of stroke, cardio-vascular disease, hyperlipidemia, and cerebro-vascular disease, etc [1][2][3] . At present, studies toward Salvia miltiorrhiza activity are mainly concentrated on salvianolic acid, tanshinones and caffeic acid and their pharmacology function [4] . Flavones compound is a significant bioactive substance which can enhance immune function for antitumor, anticoagulation, blood fat regulation, anti-aging, anti-virus, etc [5,6] .…”

Section: Introductionmentioning

confidence: 99%

Extraction and Antioxidant Activity of Flavones from Salvia miltiorrhiza

Jia¹

2015

Proceedings of the International Conference on Advances in Energy, Environment and Chemical Engineering

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1. Objective: Salvia miltiorrhiza is a traditional Chinese herb medicine and is widely used in clinic application. This study is intended to extract flavones from Salvia miltiorrhiza by ultrasonic method in order to evaluate its antioxidation activity. 2. Methods: (1) Spectrophotometry is used to determine content of flavones from Salvia miltiorrhiza; (2) Ultrasonic method was used to extract flavones from Salvia miltiorrhiza and 80% ethanol-water as the solution. The effect of the different volume of solvent, extraction time and frequency were conducted (3) The antioxidation of Salvia miltiorrhiza flavones is evaluated by pyrogallol autoxidation and deoxyribose degradation. 3. Results: (1) Phenol -sulfuric acid method was established to test the content of flavones from Salvia miltiorrhiza. The results were in good linear relationship, and y = 0.0119 x -0.0061, R 2 = 0.9996. (2) The extraction process of Salvia miltiorrhiza flavones by ultrasonic method was 5g raw material, 245mL 80% ethanol-water solution, twice extraction, 40 min for each. (3) Antioxidtion tests indicated that with the concentration 0.05mg/mL of flavones, the inhibition rate for superoxide anion radical could reach 76.89% and 58.54% for hydroxyl radical, respectively. And the reducing power was likely to increase with the increasing of flavones concentration. 4. Conclusion: Ultrasonic method could effectively extract flavones from Salvia miltiorrhiza. Antioxidation tests indicate that flavones from Salvia miltiorrhiza have a certain removal effect on superoxide anion radical and hydroxyl radical.

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“…It is mainly used in treatment of stroke, cardio-vascular disease, hyperlipidemia, and cerebro-vascular disease, etc [1][2][3] . At present, studies toward Salvia miltiorrhiza activity are mainly concentrated on salvianolic acid, tanshinones and caffeic acid and their pharmacology function [4] . Polysaccharides compound is a significant bioactive substance which can enhance immune function for antitumor, anticoagulation, blood fat regulation, anti-aging, anti-virus, etc [5,6] .…”

Section: Introductionmentioning

confidence: 99%