Chemistry and Biology of Amyloid Inhibition

Disassembly of preformed amyloid beta fibrils by small organofluorine molecules

“…Therefore, the inhibition of the seeding and progress of Aβ self-assembly, complimented by the disassembly of the preformed aggregates is among the promising therapeutic options. One of the most pursued strategies is the inhibition of Aβ oligomerization and/or fibrillization by small organic molecules 5,6. Some of these studies were also extended to the reverse process; the destabilization of the preformed fibrillar aggregates 5,6,7,8.…”

“…One of the most pursued strategies is the inhibition of Aβ oligomerization and/or fibrillization by small organic molecules 5,6. Some of these studies were also extended to the reverse process; the destabilization of the preformed fibrillar aggregates 5,6,7,8. The modes of action of these molecules are still unclear, mostly due to the limited structural information available on the diverse amyloid assemblies 9,10.…”