1988
DOI: 10.1016/0098-2997(88)90002-7
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Chemistry and biology of the alginate of mucoid strains of pseudomonas aeruginosa in cystic fibrosis

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Cited by 72 publications
(48 citation statements)
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“…This extracellular matrix of glycocalyx in the form of exopolysaccharide of biofilms of P. aeruginosa is mainly composed of alginate. Alginate is an acetylated polymer of beta-D-mannouronic acid and alpha-L-guluronic acids where two uronic acids are arranged in different ways to form block structures [39][40]. Interestingly, in the present study, in biofilm cells a fall in the quantity of alginate was observed 5 th day onwards.…”
Section: Discussionsupporting
confidence: 54%
“…This extracellular matrix of glycocalyx in the form of exopolysaccharide of biofilms of P. aeruginosa is mainly composed of alginate. Alginate is an acetylated polymer of beta-D-mannouronic acid and alpha-L-guluronic acids where two uronic acids are arranged in different ways to form block structures [39][40]. Interestingly, in the present study, in biofilm cells a fall in the quantity of alginate was observed 5 th day onwards.…”
Section: Discussionsupporting
confidence: 54%
“…It has not been shown whether they also secrete alginate or another extracellular polysaccharide and, if alginate is produced, whether it has the same structure as that from mucoid isolates from CF patients. If there is a difference between mucoid strains from C F and non-CF patients, this might provide a valuable clue to the control of alginate synthesis which, like the pathway, is poorly understood (Russell and Gacesa, 1988).…”
Section: Introductionmentioning
confidence: 99%
“…Most C F patients become colonised, probably by the nonmucoid form of P. aeruginosa which later becomes mucoid (Govan and Harris, 1986). It is not known what stimulates the bacteria to synthesise alginate (Russell and Gacesa, 1988). Assumptions have been made that some factor specific to the CF condition is responsible and that the presence of mucoid P.…”
Section: Introductionmentioning
confidence: 99%
“…For example, the development of the chronic hepatitis B virus carrier state has been reported by Bar-naba et al ( 1 ) to be associated with the presence of HLA class I-restricted cytotoxic T lymphocytes (CTL)' that kill B cells producing virus-specific neutralizing antibodies. Acquisition of persistent pulmonary infection with mucoid strains ofPseudomonas aeruginosa among cystic fibrosis (CF) patients remains the major complication leading to morbidity and death (2,3). Persistence of the pathogen despite an intense immune response to bacterial antigens (4)(5)(6)(7)(8) suggests an immunologic defect specific to mucoid P. aeruginosa cells.…”
Section: Introductionmentioning
confidence: 99%