Chemistry and heterocyclization of dithiobiurea and thioureidoalkylthiourea

Abstract

This review summarizes published data on the behavior and reactions of dithiobiurea and thioureidoalkylthiourea derivatives, which lead to the formation of heterocyclic systems, including methods of preparation in addition to synthesis of imidazolidine, thiazole, thioazolidine, triazolidine, thiadiazine, and spiro compounds.

An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives

“…Numerous protocols for the synthesis of thiazolyl-linker-thiazole compounds have been reported in the literature, most of them being based on the Hantzsch condensation reaction. The reaction can occur in a single step, when the two thiazole rings are formed simultaneously, using starting compounds such as bis-thiosemicarbazones, 2,5-dithiobiurea, bis-hydrazonoyl halides, or dihalo diketones, or in two steps when the two thiazole rings are formed successively [ 94 , 95 , 96 , 97 , 98 , 99 ].…”

Bis‐thiourea Derivatives and Their Utility in Synthesis of Mono‐heterocyclic, Bis‐heterocyclic, and Fused Heterocyclic Systems

“…Bis‐thiourea derivatives were reported as key precursors for synthesis of broad heterocyclic systems of potential biological activities . They have also demonstrated interesting pharmacological activities.…”

Synthesis of bis-thiazolidin-4-ones from N,N,N″-(1,ω-alkanediyl)bis(N″-organylthiourea) derivatives

“…The 4-thiazolidinone ring system comprises a large number of biologically active compounds that have been evaluated for their anticonvulsant [7,8], antidiarrheal [9], antiplatelet activating [10], antimicrobial [3,10,11], anti-HIV [12][13][14][15], and anticancer [16][17][18] activities. Several methods for the stereoselective synthesis of thiazolidin-4-ones are available in the literature [19][20][21][22][23][24][25][26][27][28][29].…”