Chemistry and microbial sources of curdlan with potential application and safety regulations as prebiotic in food and health

Verma, Deepak Kumar; Niamah, Alaa Kareem; Patel, Ami; Thakur, Mamta; Sandhu, Kawaljit Singh; Chávez‐González, Mónica L.; Shah, Nihir; Aguilar, Cristóbal N.

doi:10.1016/j.foodres.2020.109136

Cited by 89 publications

(34 citation statements)

References 117 publications

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“…Therefore, it can be hypothesized that Euglena which only has a proteinaceous pellicle membrane as outer covering might be more susceptible to leakage leading to paramylon and other cellular components release which might have aided in the Lactobacilus growth. Curdlan, another β-(1 → 3)-d-glucan oligosaccharides have been reported to improve the growth of variety of Lactobacillus as well as Bifidobacterium species ( Shi et al., 2018 ; Verma et al., 2020 ). Curdlan is also a liner β-1,3-glucan similar to paramylon albeit it is soluble as opposed to that of later which is insoluble.…”

Section: Resultsmentioning

confidence: 99%

Prebiotic activity of paramylon isolated from heterotrophically grown Euglena gracilis

Bhattad¹,

Koradiya

Prakash³

2021

Heliyon

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Resultsmentioning

confidence: 99%

Prebiotic activity of paramylon isolated from heterotrophically grown Euglena gracilis

Bhattad¹,

Koradiya

Prakash³

2021

Heliyon

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“…Curdlan sulfate as a vaccine against the infection of hepatitis B virus (HBV), treatment of severe malaria [47] Antioxidant and antitumor activities [48]…”

Section: Paenibacillus Polymyxamentioning

confidence: 99%

Biomedical Applications of Bacterial Exopolysaccharides: A Review

et al. 2021

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Bacterial exopolysaccharides (EPSs) are an essential group of compounds secreted by bacteria. These versatile EPSs are utilized individually or in combination with different materials for a broad range of biomedical field functions. The various applications can be explained by the vast number of derivatives with useful properties that can be controlled. This review offers insight on the current research trend of nine commonly used EPSs, their biosynthesis pathways, their characteristics, and the biomedical applications of these relevant bioproducts.

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“…Curdlan falls into the category of neutral gel having β-(1→ 3)-glycosidic linkage or may also contain few inter-and intra-chain (1→ 6)-linkages, which contain almost 10% succinate known as succinoglycan (36). Curdlan is produced in three different structural forms by the bacterial species (28).…”

Section: Chemical Structures/formulas Of Curdlan Productsmentioning

confidence: 99%

Therapeutic and Industrial Applications of Curdlan With Overview on Its Recent Patents

et al. 2021

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Curdlan is an exopolysaccharide, which is composed of glucose linked with β-(1,3)-glycosidic bond and is produced by bacteria, such as Alcaligenes spp., Agrobacterium spp., Paenibacillus spp., Rhizobium spp., Saccharomyces cerevisiae, Candida spp., and fungal sources like Aureobasidium pullulan, Poria cocos, etc. Curdlan has been utilized in the food and pharmaceutical industries for its prebiotic, viscosifying, and water-holding properties for decades. Recently, the usefulness of curdlan has been further explored by the pharmaceutical industry for its potential therapeutic applications. Curdlan has exhibited immunoregulatory and antitumor activity in preclinical settings. It was observed that curdlan can prevent the proliferation of malarial merozoites in vivo; therefore, it may be considered as a promising therapy for the treatment of end-stage malaria. In addition, curdlan has demonstrated potent antiviral effects against human immunodeficiency virus (HIV) and Aedes aegypti virus. It has been suggested that the virucidal properties of curdlans should be extended further for other deadly viruses, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and the current severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2/COVID-19). The prebiotic property of curdlan would confer beneficial effects on the host by promoting the growth of healthy microbiota in the gut and consequently help to reduce gastrointestinal disorders. Therefore, curdlan can be employed in the manufacture of prebiotics for the management of various gastrointestinal dysbiosis problems. Studies on the mechanism of action of curdlan-induced suppression in microbial and tumor cells at the cellular and molecular levels would not only enhance our understanding regarding the therapeutic effectiveness of curdlan but also help in the discovery of new drugs and dietary supplements. The primary focus of this review is to highlight the therapeutic interventions of curdlan as an anticancer, anti-malaria, antiviral, and antibacterial agent in humans. In addition, our review provides the latest information about the chemistry and biosynthesis of curdlan and its applications for making novel dairy products, functional foods, and nutraceuticals and also details about the recent patents of curdlan and its derivatives.

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Chemistry and microbial sources of curdlan with potential application and safety regulations as prebiotic in food and health

Cited by 89 publications

References 117 publications

Prebiotic activity of paramylon isolated from heterotrophically grown Euglena gracilis

Prebiotic activity of paramylon isolated from heterotrophically grown Euglena gracilis

Biomedical Applications of Bacterial Exopolysaccharides: A Review

Therapeutic and Industrial Applications of Curdlan With Overview on Its Recent Patents

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