2010
DOI: 10.1007/s12272-010-1101-9
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Chemistry and pharmacological action of caffeoylquinic acid derivatives and pharmaceutical utilization of chwinamul (Korean Mountainous vegetable)

Abstract: Chwinamul is a mountainous vegetable that refers to several species belonging to the family Compositae. Chwinamul has been used as a side dish or a medicinal herb to treat hypercholesterolemia, diabetes, common cold, atherosclerosis, and cardiovascular disease. Caffeoylquinic acids (CQs) are present in high levels in chwinamul, though caffeoyltartaric acids (CTs) are often occurred in the vegetables of Compositae. Here I review the chemical and pharmaceutical aspects of CQs and CTs. In particular, ¹³C-NMR data… Show more

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Cited by 39 publications
(17 citation statements)
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“…Caffeoylquinic acids are free radical and metal scavengers and have been shown to modulate the gene expression of antioxidant enzymes [32]. Also, they have neuroprotective, neurotrophic [33], and hepatoprotective activity [34]. …”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Caffeoylquinic acids are free radical and metal scavengers and have been shown to modulate the gene expression of antioxidant enzymes [32]. Also, they have neuroprotective, neurotrophic [33], and hepatoprotective activity [34]. …”
Section: Resultsmentioning
confidence: 99%
“…This compound represented up to 75% of the sum of the tricaffeoylquinic acids detected in transformed roots (Table 4). The tricaffeoylquinic acids and their derivatives are less common in plants than mono-, and dicaffeoyl ones [34]. This type of compounds was earlier identified in other species of family Asteraceae, such as Arnica montana [21] and Erigeron breviscapus [20].…”
Section: Resultsmentioning
confidence: 99%
“…The alteration of the activities of lipid metabolism enzymes such as hepatic lipase (HL), lipoprotein lipase (LPL) and 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR) are also involved in the anti-hyperlipidemic activities of chlorogenic acid [47], [48], [50], [51]. The beneficial effects of CQAs on hyperglycemia and hyperlipidemia have also been reported [52], [53]. Therefore, caffeoylquinic acids may be the active components of the PTF-b used for the treatment of hyperlipidemia.…”
Section: Discussionmentioning
confidence: 99%
“…63,64,66 Incomplete signal resolution, producing inaccurate coupling constants, has generated unconvincing structural assignments, notably reports of acyl-quinic acids containing a stereo-isomer of 1L-(À)-quinic acid. [67][68][69][70][71][72][73] These novel compound(s) are rarely observed in company with a full set of the commoner 1L-(À)-quinic acid derivatives. This does not per se refute the claim, but might suggest that one of the commoner acyl-quinic acids has been wrongly identied.…”
Section: H-nmrmentioning
confidence: 99%