Chemistry and pharmacological aspects of Aridanin, a lead compound from <i>Tetrapleura tetraptera</i> (Fabaceae)

Abstract

Aridanin, a triterpenoid N-acetylglycoside has been obtained from chemical investigations of the root of &lt;i&gt;Tetrapleura tetraptera&lt;/i&gt;, a well-known seasoning spice from Cameroonian food. The structure of the compound has been established using its NMR data and by comparison of that data with the one reported in the literature. Further evidence has been compiled from literature and discussed on the occurrence, the extraction, isolation and analytical techniques as well as the reported biological activities of aridanin. Based on its potency and its high yield in &lt;i&gt;Tetrapleura tetraptera&lt;/i&gt; fruits, the compound can be considered as lead compound in the development of medicine for the control of schistosomiasis and bacterial infections caused by the bacterial strains&lt;i&gt;E. coli&lt;/i&gt;, &lt;i&gt;E. smartii&lt;/i&gt; and &lt;i&gt;E. aeroginese&lt;/i&gt;. this paper sheds light on the compound aridanin which deserves more attention in the development of a new potent drug or on the formulation of &lt;i&gt;Tetrapleura tetraptera&lt;/i&gt; for effective use by the local population.

Chemical constituents of <i>Citrus grandis</i> (L.) Osbeck (Rutaceae) and their α-glucosidase inhibitory activity

“…The presence of acridone alkaloids in C. grandis species is not a surprise, because that subclass of alkaloids is considered as the chemomarkers of Citrus. This work therefore brings a significant contribution to the chemotaxonomic knowledge of the species C. grandis, further identified here as a new source of aridanin (1) which was already reported from several other plant families (Sikam et al, 2023).…”

“…From the literature survey, we reported that aridanin (1) displayed some significant pharmacological activities including molluscicidal potency by reducing the level of glycogen of Biomphalaria glabrata during a period of exposure up to 4 weeks; while its antischistosomal potency was observed through the ability of the compound to diminish the transmission of schistosomiasis by dropping the cercariae production (Adewunmi et al, 1988;Adewunmi & Furu, 1989). Additionally, aridanin (1) also showed antibacterial, cytotoxic, trypanocidal and antiviral activities, which further support its importance in the development of new potent drugs (Sikam et al, 2023).…”

“…Recently, we have published a comprehensive review on the chemistry, occurrence and pharmacological properties of aridanin (1), a lead compound found in the spice Tetrapleura tetraptera (Fabaceae) and several other medicinal plants (Sikam et al, 2023).…”