Chemistry and Pharmacology of Cyperaceae Stilbenoids: A Review

Abstract

Cyperaceae is a cosmopolitan plant family with approx. 5000 species distributed worldwide. Several members of this family are used in traditional medicines for the treatment of different diseases. In the last few decades, constituents with great chemical diversity were isolated from sedges, and a wide range of biological activities were detected either for crude extracts or for pure compounds. Among the isolated compounds, phenolic derivatives are the most important, especially stilbenoids, and flavonoids. To date, more than 60 stilbenoids were isolated from 28 Cyperaceae species. Pharmacological investigation of Cyperaceae stilbenoids revealed that several compounds possess promising activities; mainly antiproliferative, antibacterial, antioxidant and anthelmintic effects. Isolation, synthesis and pharmacological investigation of stilbenes are increasing constantly. As Cyperaceae species are very good sources of a wide variety of stilbenes, and several of them occur in large amount worldwide, they are worthy for phytochemical and pharmacological investigations. Moreover, stilbenes are important from chemotaxonomical point of view, and they play a key role in plant defense mechanisms as well. This review summarizes the stilbenoids isolated from sedges, and their biological activities.

In Silico Identification and Evaluation of Natural Products as Potential Tumor Necrosis Factor Function Inhibitors Using Advanced Enalos Asclepios KNIME Nodes

“…These compound classes have been shown to possess a wide range of multifaceted activities of pharmacological interest, stretching from anticancer, antimicrobial, antioxidant, anti-inflammatory, antiplatelet, antidiabetic, hepato-, cardio- and neuroprotective, spasmolytic to tyrosinase inhibitory and ecdysteroid antagonist activities [ 57 , 58 , 59 ].…”

“…Both cis-Miyabenol C and trans-Miyabenol C are resveratrol trimers. Cis-Miyabenol C is obtained by various Vitis, Muscadinia and Carex species; its pharmacological interest concerns inhibition of amyloid β fibril formation and ecdysteroid antagonist activity [ 58 , 64 , 65 , 66 ]. Trans-Miyabenol C is obtained by Caragana sinica of Leguminosae and various Vitis, Muscadinia and Carex species; it has been found to inhibit protein kinase C while presenting antioxidant activity [ 58 , 64 , 65 , 67 , 68 ].…”

“…Cis-Miyabenol C is obtained by various Vitis, Muscadinia and Carex species; its pharmacological interest concerns inhibition of amyloid β fibril formation and ecdysteroid antagonist activity [ 58 , 64 , 65 , 66 ]. Trans-Miyabenol C is obtained by Caragana sinica of Leguminosae and various Vitis, Muscadinia and Carex species; it has been found to inhibit protein kinase C while presenting antioxidant activity [ 58 , 64 , 65 , 67 , 68 ]. Cis- and trans-Diptoindonesin B are stilbenoids, resveratrol trimers which were isolated from the plant Dryobalanops oblongifolia Dipterocarpaceae [ 69 ].…”

“…A recent in silico study suggested that they may act as sirtuine1 enzyme inhibitors, therefore demonstrating anticancer activity [ 70 ]. Additionally, Kobophenol A is a stilbene, resveratrol tetramer that has been isolated from various plants: Caragana sinica of Leguminosae [ 67 ], Carana sinica of Fabaceae [ 71 ], and many Carex Cyperaceae species (e.g., Carex kobomugi, Carex buchananii, Carex cuprina, and Carex folliculate) [ 58 , 72 ]. It has exhibited anti-inflammatory activity by downregulating the NF-κB signaling pathway that mediates inflammation [ 71 ].…”

A Themed Issue in Honor of Professor K. Hüsnü Can Baser—Outstanding Contributions in the Fields of Pharmacognosy, Phytochemistry, Botany and Ethnopharmacology

“…The main aim of their study was to present an up-to-date account of the botany, chemistry, and traditional uses of the family in southern Africa. In another review paper by Andrea Vasas and colleagues [ 10 ], the information concerning stilbenoids occurring in Cyperaceae species is summarized. The authors focused on the isolation, synthesis, and pharmacological properties of this group of compounds in addition to their chemotaxonomical significance.…”