Chemistry and Pharmacology of Honey-bee Venom

Banks, Barbara E. C.; Shipolini, Rudolf A.

doi:10.1016/b978-0-12-554770-3.50011-5

Cited by 89 publications

(84 citation statements)

References 241 publications

(177 reference statements)

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“…venom included phospholipase A2, hyaluronidase, acid phosphomonoesterase, α-D-glucosidase, and lysophospholipase (Somerfield et al, 1984;Banks and Shipolini, 1986). Among them, melittin, a water-soluble cationic amphipathic 26 amino acid α-helical peptide, is a very nonspecific cytolytic peptide that attacks all lipid membranes leading to significant toxicity (Pan et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

The Antifungal Activity of Bee Venom against Dermatophytes

Yu¹,

Kim²,

Park³

et al. 2012

Journal of Applied Biological Chemistry

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The antifungal activities of the bee venom against Trichophyton mentagrophytes and Trichophyton rubrum were determined by using modified broth dilution assay. The most common dermatophytes, named T. mentagrophytes and T. rubrum, were known to cause a variety of cutaneous infections in humans and animals. The bee venom exhibited prominent antifungal activities against the two dermatophytes tested in this investigation. Moreover, the antifungal activities of the bee venom were much stronger than that of fluconazole, one of the commercial antifungal drugs used in the treatment and prevention of superficial and systemic fungal infections. The result suggests that bee venom could be developed as a natural antifungal drug.

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Section: Discussionmentioning

confidence: 99%

The Antifungal Activity of Bee Venom against Dermatophytes

Yu¹,

Kim²,

Park³

et al. 2012

Journal of Applied Biological Chemistry

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“…4b). Gaegurin 5, isolated from the skin of the frog Rana rugosa (28,29), exhibits a broad spectrum of antimicrobial action against bacteria, fungi, and protozoa but has very little hemolytic action, in contrast to the ponericins W. Melittin is the major toxic component of the venom of honey bees and also has high antimicrobial and hemolytic activities (16,30).…”

Section: Discussionmentioning

confidence: 99%

Ponericins, New Antibacterial and Insecticidal Peptides from the Venom of the Ant Pachycondyla goeldii

Orivel

Redeker

Caër

et al. 2001

Journal of Biological Chemistry

204

202

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The antimicrobial, insecticidal, and hemolytic properties of peptides isolated from the venom of the predatory ant Pachycondyla goeldii, a member of the subfamily Ponerinae, were investigated. Fifteen novel peptides, named ponericins, exhibiting antibacterial and insecticidal properties were purified, and their amino acid sequences were characterized. According to their primary structure similarities, they can be classified into three families: ponericin G, W, and L. Ponericins share high sequence similarities with known peptides: ponericins G with cecropin-like peptides, ponericins W with gaegurins and melittin, and ponericins L with dermaseptins. Ten peptides were synthesized for further analysis. Their antimicrobial activities against Gram-positive and Gram-negative bacteria strains were analyzed together with their insecticidal activities against cricket larvae and their hemolytic activities. Interestingly, within each of the three families, several peptides present differences in their biological activities. The comparison of the structural features of ponericins with those of well-studied peptides suggests that the ponericins may adopt an amphipathic ␣-helical structure in polar environments, such as cell membranes. In the venom, the estimated peptide concentrations appear to be compatible with an antibacterial activity in vivo. This suggests that in the ant colony,

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“…However, in the defense aspect, the most effective is the venom of honey bee (Apis mellifera L.) (O'Connor, et al, 1967). The main component of this toxin is melittin, one of the most effective detergents that causing red blood cell haemolysis and damage cells of muscles (Banks & Shipolini, 1986;Nabil et al, 1988). The V. crabro venom can be used not only to defend the colony and rarely to attack on other insects in order to acquire food, but it is also an effective tool to combat individuals of hornet from foreign societies (Nadolski, 2013) In conclusion of these results, it is very important that people who are near wasp colonies should have clothes in white or green and hair obscured but when removing whole nests a man have to have a safe outfit properly constructed.…”

Section: Resultsmentioning

confidence: 99%

Effects of Colors and Appearance of the Potential Aggressor on Defensive Behavior of Vespa crabro L. (Hymenoptera: Vespidae) Colonies.

Nadolski¹

2013

Sociobiology

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Defensive behavior of the European hornet Vespa crabro colonies were studied using the dummy and balloons in different colors. The strong aggressiveness level of hornet's workers was caused by dark colors (black and brown) and orange. The colors white and green did not cause their attack. However, the strongest reactions of hornets were caused by dummy with the animal snout and dark hair on the head. Thus people who are near wasp colonies should have clothes in white or green and hair obscured but when the whole nest is eliminate, they have to have a safe outfit properly constructed.

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Chemistry and Pharmacology of Honey-bee Venom

Cited by 89 publications

References 241 publications

The Antifungal Activity of Bee Venom against Dermatophytes

The Antifungal Activity of Bee Venom against Dermatophytes

Ponericins, New Antibacterial and Insecticidal Peptides from the Venom of the Ant Pachycondyla goeldii

Effects of Colors and Appearance of the Potential Aggressor on Defensive Behavior of Vespa crabro L. (Hymenoptera: Vespidae) Colonies.

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