Chemistry and technology of the antitumor drug glycifon

Muslinkin, A. A.; Levin, Ya. A.; Gozman, I. P.; Beschastnova, T. N.; Vorkunova, E. I.; Trutneva, E. K.; Gazizova, L.Kh.; Gurylev, E. A.; Studentsova, I. A.; Гараев, Р. С.; Berdnik, I. V.

doi:10.1007/bf02524637

Cited by 2 publications

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“…55 Currently, vacuum distillation is mainly used for separation and processing applications including crude oil refining as well as food and drug processing. 56,57 In addition to extracting thermally sensitive materials, distilling at reduced pressures can decrease the overall cost and time needed for identical processing at atmospheric pressure. 58 The standard test method for reduced pressure volatility measurements (distillation curve) is ASTM D-1160 (at reduced pressures: 0.13 kPa-6.7 kPa), which suffers from many of the same drawbacks as ASTM D-86 mentioned above.…”

Section: Introductionmentioning

confidence: 99%

“…This will be manifest by the leveling of the distillation curve and is problematic because the volatility measurements being made do not reflect the composition of the neat starting fluid. , The resulting thermal degradation can be overcome by performing the distillation at reduced pressures, which reduces the component boiling temperatures . Currently, vacuum distillation is mainly used for separation and processing applications including crude oil refining as well as food and drug processing. , In addition to extracting thermally sensitive materials, distilling at reduced pressures can decrease the overall cost and time needed for identical processing at atmospheric pressure . The standard test method for reduced pressure volatility measurements (distillation curve) is ASTM D-1160 (at reduced pressures: 0.13 kPa−6.7 kPa), which suffers from many of the same drawbacks as ASTM D-86 mentioned above .…”

Section: Introductionmentioning

confidence: 99%

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Improvements in the Measurement of Distillation Curves. 5. Reduced Pressure Advanced Distillation Curve Method

Windom¹,

Bruno²

2011

Ind. Eng. Chem. Res.

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The distillation curve is the only practical measurement used to characterize the vapor/liquid equilibrium (volatility) of a complex mixture. In earlier work, we described an improved method and apparatus for measurement of distillation curves at atmospheric pressure, called the advanced distillation curve (ADC) that is especially applicable to the characterization of fuels and complex mixtures. While the ADC method has greatly improved volatility measurements performed at atmospheric pressure, it still encounters problems with applications to fluids of very low volatility. Performing atmospheric pressure distillations on fluids with high boiling temperatures (350°C-450°C) can lead to thermal degradation, cracking, or polymerization of the sample. By performing the distillation at reduced pressures, one can reduce such thermal effects by reducing the component boiling temperatures. In this paper, we present a new apparatus and method that provides precise volatility measurements at reduced pressures. This new apparatus allows for nearly complete control of state variables (temperature, pressure, and composition) while volatility measurements are performed and also provides a composition-explicit data channel for each distillate fraction. Volatility measurements using the reduced pressure ADC apparatus were made on multiple samples, including two well characterized validation mixtures and a commercially available soy derived biodiesel fuel. In addition, chemical analyses were performed on the distillate fraction aliquots by use of gas chromatography-mass spectrometry. The results from the reduced pressure ADC were compared to predicted data by use of an equation of state model as well as distillation data measured at atmospheric pressure.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Improvements in the Measurement of Distillation Curves. 5. Reduced Pressure Advanced Distillation Curve Method

Windom¹,

Bruno²

2011

Ind. Eng. Chem. Res.

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“…Glyciphon, a therapeutic agent with activity against skin tumors and precancerous conditions, is a liquid with a high melting temperature [1]. Preparation of glyciphon of pharmacopeia quality requires the technical-quality chemical synthesis product to be purified by vacuum distillation.…”

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confidence: 99%

Search for the optimal conditions for the distillation of the antibacterial agent glyciphon

2007

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Preparation of the high-boiling-point organophosphate antiblastoma agent glyciphon at maximal yield and purity was addressed at the experimental production stage by studying its vacuum distillation by mathematical modeling. The optimum conditions for performing this final stage of the technical process allowed the number of distillations to be decreased and the yield of pharmacological purity product to be increased by an average of 20%. 323 0091-150X/07/4106-0323

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Chemistry and technology of the antitumor drug glycifon

Cited by 2 publications

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Improvements in the Measurement of Distillation Curves. 5. Reduced Pressure Advanced Distillation Curve Method

Improvements in the Measurement of Distillation Curves. 5. Reduced Pressure Advanced Distillation Curve Method

Search for the optimal conditions for the distillation of the antibacterial agent glyciphon

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