Chemistry, Biological Activities, and Uses of Resin of Boswellia serrata Roxb.

Alam, Tanveer; Khan, Shah Alam; Najam, Lubna

doi:10.1007/978-3-030-76523-1_25-1

Reference Series in Phytochemistry

2021

DOI: 10.1007/978-3-030-76523-1_25-1

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Chemistry, Biological Activities, and Uses of Resin of Boswellia serrata Roxb.

Tanveer Alam¹,

Shah Alam Khan²,

Lubna Najam³

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Cited by 4 publications

References 108 publications

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The journey of boswellic acids from synthesis to pharmacological activities

Ragab,

Abd El-Wahab,

Doghish

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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There has been a lot of interest in using naturally occurring substances to treat a wide variety of chronic disorders in recent years. From the gum resin of Boswellia serrata and Boswellia carteri, the pentacyclic triterpene molecules known as boswellic acid (BA) are extracted. We aimed to provide a detailed overview of the origins, chemistry, synthetic derivatives, pharmacokinetic, and biological activity of numerous Boswellia species and their derivatives. The literature searched for reports of B. serrata and isolated BAs having anti-cancer, anti-microbial, anti-inflammatory, anti-arthritic, hypolipidemic, immunomodulatory, anti-diabetic, hepatoprotective, anti-asthmatic, and clastogenic activities. Our results revealed that the cytotoxic and anticancer effects of B. serrata refer to its triterpenoid component, including BAs. Three-O-acetyl-11-keto—BA was the most promising cytotoxic molecule among tested substances. Activation of caspases, upregulation of Bax expression, downregulation of nuclear factor-kappa B (NF-kB), and stimulation of poly (ADP)-ribose polymerase (PARP) cleavage are the primary mechanisms responsible for cytotoxic and antitumor effects. Evidence suggests that BAs have shown promise in combating a wide range of debilitating disease conditions, including cancer, hepatic, inflammatory, and neurological disorders. Graphical abstract

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The journey of boswellic acids from synthesis to pharmacological activities

Ragab,

Abd El-Wahab,

Doghish

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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show abstract

Topical formulation of Boswellia nano emulsion in psoriasis mouse model

Fereidouni,

Shadi,

Mahmoudian

et al. 2024

Arch Dermatol Res

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Pharmacokinetics of a Natural Self-emulsifying Reversible Hybrid-Hydrogel (N’SERH) Formulation of Full-Spectrum <i>Boswellia serrata</i> Oleo-Gum Resin Extract: Randomised Double-Blinded Placebo-Controlled Crossover Study

Joseph,

Abhilash,

Mulakal

et al. 2024

Biological & Pharmaceutical Bulletin

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Chemistry, Biological Activities, and Uses of Resin of Boswellia serrata Roxb.

Cited by 4 publications

References 108 publications

The journey of boswellic acids from synthesis to pharmacological activities

The journey of boswellic acids from synthesis to pharmacological activities

Topical formulation of Boswellia nano emulsion in psoriasis mouse model

Pharmacokinetics of a Natural Self-emulsifying Reversible Hybrid-Hydrogel (N’SERH) Formulation of Full-Spectrum <i>Boswellia serrata</i> Oleo-Gum Resin Extract: Randomised Double-Blinded Placebo-Controlled Crossover Study

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