1958
DOI: 10.1016/s0065-230x(08)60415-7
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Chemistry, Carcinogenicity, and Metabolism of 2-Fluorenamine and Related Compounds

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Cited by 164 publications
(18 citation statements)
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“…2-Acetylaminofluorene (AAF) is a potent carcinogen to the rat liver (38,39), where it undergoes bioactivation to a DNA-reactive ultimate carcinogen (48). In Fischer-344 (F-344) male rats, administration of AAF produces a rapid appearance of hepatocellular altered foci in the liver characterized by a variety of abnormalities (10, 15, 16, 18-20, 35, 40, 46, 49).…”
Section: Introductionmentioning
confidence: 99%
“…2-Acetylaminofluorene (AAF) is a potent carcinogen to the rat liver (38,39), where it undergoes bioactivation to a DNA-reactive ultimate carcinogen (48). In Fischer-344 (F-344) male rats, administration of AAF produces a rapid appearance of hepatocellular altered foci in the liver characterized by a variety of abnormalities (10, 15, 16, 18-20, 35, 40, 46, 49).…”
Section: Introductionmentioning
confidence: 99%
“…Pour plates were prepared as described in Methods, incorporating into the top agar TA1538, [5][6][7][8][9][10] MlI of test solution, and 0.5 ml of 8-9 Mix containing various amounts of 8-9 as indicated.…”
Section: Resultsmentioning
confidence: 99%
“…These include 2-amino-and 2-acetamido-fluorene (Weisburger and Weisburger, 1958), urethane (Cowen, 1950 and implanted plastic film (Stinson, 1960). There are also reports on the rarity of spontaneous tumours in the guinea-pig (Warren and Gates, 1941;Lombard, 1960;Mosinger, 1961).…”
Section: Discussionmentioning
confidence: 99%