Chemistry of 3-(2-Haloacyl)indoles

Novel Pyrazolo[1,5‐a]Pyrimidines and Pyrazolo[5,1‐c][1,2,4]Triazines Incorporating Indole Moiety as a New Class of Antioxidant Agents

“…The presence of these derivatives at the 3‐position of indole nucleus may dramatically open extra opportunities for their utilization in pharmaceutical chemistry in recent years. Recently, we have described and reviewed an efficient synthesis of some 3‐substituted indoles incorporating bioactive heterocyclic compounds . Motivated by the previous facts and considering the wide range of pharmacological significance of 3‐substituted indole, we present here simple and facile protocol for the efficient regioselective synthesis of a new class of pyrazolo[1,5‐ a ]pyrimidines and pyrazolo[5,1‐ c ][1,2,4]triazines at the 3‐position of indole fragment to investigate the antioxidant activity.…”