Chemistry of 3-hydroxy-2-aryl acrylate: syntheses, mechanisms, and applications

Abstract

3-Hydroxy-2-aryl acrylate is important scaffold which is widely used for the synthesis of pharmacologically active compounds. This review summarises the synthetic methods of the 3-hydroxy-2-aryl acrylate including mechanisms and applications.

Synthetic Scope of Brønsted Acid-Catalyzed Reactions of Carbonyl Compounds and Ethyl Diazoacetate

“…They are also exploited as common monomers in the polymer industry . Moreover, such oxo-esters and their related acrylates contribute to very unusual Michael and Mannich type reactions. − Therefore, increasing efforts have been devoted to developing efficient protocols for the synthesis of these vital scaffolds using commercially available starting materials …”

“…7−10 Therefore, increasing efforts have been devoted to developing efficient protocols for the synthesis of these vital scaffolds using commercially available starting materials. 11 In our previous work, we reported the formation of 3hydroxy-2-aryl acrylates by 1,2-aryl migration from the reactions of aromatic aldehydes with ethyl diazoacetate (EDA) in the presence of an iron Lewis acid catalyst. 12 Later on, other groups also reported the similar type of reactions using different Lewis acid catalysts.…”