Chemistry of Collagen Crosslinking: Relationship to Aging and Nutrition

McClain, Philip E.

doi:10.1007/978-1-4757-9113-6_34

Cited by 14 publications

(8 citation statements)

References 28 publications

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“…The biosyn thesis of subcutaneous collagen and noncollagenous protein was depressed by zinc de ficiency in young rats (11). McClain et al (12,13) observed that the incorporation of [2-14C]glycine into a! and a2 chains and L-[U-HC]proline into the salt-soluble collagen frac tion were depressed in skin from zinc-defi cient rats.…”

Section: Discussionmentioning

confidence: 99%

“…In rats, zinc deficiency profoundly im-While it is evident that zinc is essential for growth, its role in bone formation is not fully @1982 American Institute ofNulrition Received for^^â€ž paired the synthesis of collagen and possibly its cross-linkage (11)(12)(13). The decreased breaking strength of healing surgical wounds in zinc deficient rats may be related to these abnormalities (14).…”

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confidence: 99%

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Epiphyseal Plate Development in the Zinc-Deficient Rat

Suwarnasarn

Wallwork

Lykken

et al. 1982

The Journal of Nutrition

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The effect of zinc deficiency on shearing strength, histological changes and proline utilization of the epiphyseal plate of the tibia of the weanling male rat was studied. A diet was fed based on sprayed egg white and containing less than 2 mg of zinc per kilogram. Over 27 day, the force required to displace the epiphysis of the zinc-deficient (ZD) rats was always less than that required for pair-fed (PF) controls. After 18 days, approximately 15% more force was required to displace the epiphysis of the PF rats than was required in the ZD rats. The thickness of the outside compact bone next to the epiphyseal plate region as determined by scanning electron microscopy was thicker in the ZD rats than in the PF controls of comparable age. The epiphyseal plates narrowed as the rats aged, and were clearly discernible in PF controls but not in ZD rats. The incorporation of L-[U-14C]proline into the epiphysis was significantly less in rats deprived of zinc for 16-22 days than in PF controls.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Epiphyseal Plate Development in the Zinc-Deficient Rat

Suwarnasarn

Wallwork

Lykken

et al. 1982

The Journal of Nutrition

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“…Changes in collagenous tissues that occur with increasing age have been presented in many biochemical studies [1][2][3][4][5][6][7] and studies of mechanical shrinkage of collagen to heat or chemical environments [8][9][10][11][12][13]. These studies have been conducted primarily with tissue from nonhuman animals from birth to maturity, a period from a few months to a few years.…”

Section: Introductionmentioning

confidence: 99%

Mechanical Properties of Human Tendon and Their Age Dependence

Hubbard

Soutas-Little

1984

Journal of Biomechanical Engineering

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There are no previously published data on changes in the mechanical behaviors of human tendon from maturation in the second decade to senectitude in the seventh decade or thereafter. In this study, 44 tendons from individuals ranging in age from 16 to 88 yr were subjected to an extensive series of mechanical tests which included preconditioning, extensions at strain rates of 100 percent/s, 1 percent/s, and 0.01 percent/s, and stress relaxation with cyclic and constant extensions. Pairs of extensions at 1 percent/s were run throughout the protocol to evaluate the repeatability of tissue response. It was found that these responses changed little for any single sample within a pair of such tests; however, throughout the protocol, the peak stresses and moduli decreased. Extensions at different rates revealed a definite rate dependency of tendon responses with sample modulus being directly related to extension rate and slightly less hysteresis at 1 percent/s than at 100 percent/s or 0.01 percent/s. The load relaxation in samples subjected to either cyclic or constant extensions was generally best described by a linear function of the logarithm of time. The rate of relaxation with constant extension varied little with extension magnitude. The rate of relaxation in the cyclic tests was greater at 10 Hz than at 0.1 Hz. The results indicate that subject age has no effect on tendon modulus and a very small effect on hysteresis and relaxation. Extensive information on subject history was not available in this study for correlation with mechanical responses so that an age effect may have been masked by other variables, possibly health, diet, disease, or exercise.

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“…McClain (1977) reported that the type and extent of cross-linking in intramuscular collagen are influenced by animal age, and possibly by nutritional status of the animals, as well. Harris (1976) stressed the importance of avoiding myofibrillar contraction when looking for treatment effects other than those directly related to cold shortening.…”

Section: Introductionmentioning

confidence: 99%