Chemistry of Fungicidal Action

Lukens, Raymond J.

doi:10.1007/978-3-662-11311-0

Cited by 54 publications

(37 citation statements)

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“…This result confirms captan non-specific thiol reactivity as one of the most important direct effects of the phtalimide fungicides [3]. Moreover, captan-treated cells exhibited a drastic loss of membrane integrity, a typical necrotic behavior [16], which can be the result of the modification of membrane protein structures by protein sulfhydryldisulfide transitions, and consequent increase in membrane permeability [17].…”

Section: Resultssupporting

confidence: 68%

“…Captan reaction with thiol groups has been pointed as the main mode of action on phytopathogenic fungi, been responsible for the reduction of enzymatic activities, respiration, physiological changes, and fungal death [3]. In the presence of exposed thiol groups, captan oxidize thiols and is hydrolyze to its reactive thiophosgene (SCCl 3 ) moiety, and the 1,2,3,6-tetrahydrophthalimide ring [4].…”

Section: Introductionmentioning

confidence: 99%

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The effect of the fungicide captan onSaccharomyces cerevisiaeand wine fermentation

et al. 2016

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Abstract. Fungicides, particularly those used during grape maturation, as captan, can affect the natural yeast population of grapes, and can reach grape must affecting wine fermentation. The objective of the present work was to study the effect of captan on the viability and fermentative behavior of S. cerevisiae. S. cerevisiae (BY4741) on exponential phase was treated with captan (0 to 40 µM) for different periods, and their cell viability analyzed. Cell membrane integrity, thiols concentration, and reactive oxygen species (ROS) accumulation was determined. The fermentation experiments were conducted in synthetic must using wine yeast strain Y904. The results showed that under aerobic conditions, 20 µM of captan reduce 90% of yeast viability in 6 hours. Captan treated cells exhibited alteration of membrane integrity, reduction of thiol compounds and increase in intracellular ROS concentration, suggesting a necrotic and pro-oxidant activity of the fungicide. Fermentative experiments showed that concentrations above 2.5 µM captan completely inhibited fermentation, while a dose dependent fermentation delay associated with the reduction of yeast viability was detected in sub-inhibitory concentrations. Petit mutants increase was also observed. In conclusion, the captan induces yeast necrotic cell death on both aerobic and anaerobic conditions causing fermentation delay and/or sucking fermentations.

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Section: Resultssupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

The effect of the fungicide captan onSaccharomyces cerevisiaeand wine fermentation

et al. 2016

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“…tricarboxylic acid enzymes, hexokinase enzymes, triosphosphate dehydrogenase enzymes, aldolase enzymes, cocarboxylase enzymes, thiamin pyrophosphate enzymes, keto acid dehydrogenase enzymes, polyphenol oxidase enzymes, citric acid synthetase enzymes, akonitase enzymes, isositrate dehydrogenase enzymes, α-ketoglutarate dehydrogenase enzymes, succinate dehydrogenase enzymes, malate dehydrogenase enzymes and glycolytic enzymes (hexokinase, phosphohexose isomerase, phosphofructokinase, aldolase, triosa phosphate isomerase, glyceraldehyde 3-phosphate dehydrogenase, phosphoglycerate kinase, phosphoglycerate mutase, enolase and pyruvate kinase) [17].…”

Section: Discussionmentioning

confidence: 99%

“…Affects the respiratory complexes of mitochondria by disrupting the flow of electrons in the respiratory chain, causing multi-site toxicity on a broad spectrum [15,16]. Affects enzymes in mitochondria [17]. Calcium polysulfide toxicity against non-target organisms is between non-toxic to moderate toxicity [18][19][20][21].…”

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confidence: 99%

Effect of Calcium Polysulfide Applications on Severity of Cocoa Pod Rot (Phytophthora palmivora Butl.) and Fungal Diversity

Widiyasmoro

Martosudiro

Sulistyowati

2017

JELS

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Indonesian government gives a high priority for the development and revitalization of cocoa production. In 2012/2013, production of cocoa in Indonesia reached 410,000 ton from 1,774,500 ha (about 231 kg ha -1 ), lower than Ghana which is 835,000 ton from 1,600,300 ha (about 521 kg ha -1 ). One of the constraints of cocoa production in Indonesia is pod rot disease caused by Phytophthora palmivora, which can reduce about 90% of production during wet season. Calcium polysulfide was suggested as one of the potential, cheap and save substance to control P. palmivora. The purpose of this study was to evaluate the calcium polysulfide potential to control the disease and its effect on the phyllosphere-fungal diversity. A positive correlation was found between concentration of calcium polysulfide and inhibition of fungal growth in the media. Otherwise, a negative correlation was found between concentration of calcium polysulfide and fungal biomass. Disease severity of cocoa treated by calcium polysulfide 80 mL L -1 every week was 11.67% significantly lower than control, i.e. 68.33%. Furthermore, it was also found that the index value of fungal diversity on the phyllosphere decreased by increasing concentration and interval of calcium polysulfide application.

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“…The inhibitory power of substituted quinones largely depends upon their substituent group. It was found that halogenation increased inhibitory effectiveness hence chloranil (tetrachloro-1,4-benzoquinone) and dichlone (2,3-dichloro-1,4-naphthoquinone) are fungicides most frequently used [19].…”

Section: Introductionmentioning

confidence: 99%

Kinetics of jack bean urease inhibition by 2,3-dichloro-1,4-naphthoquinone. Elucidation of the mechanism: redox cycling and sulfhydryl arylation

Zaborska

Kot

Bala

2009

Journal of Enzyme Inhibition and Medicinal Chemistry

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Chemistry of Fungicidal Action

Cited by 54 publications

References 0 publications

The effect of the fungicide captan onSaccharomyces cerevisiaeand wine fermentation

The effect of the fungicide captan onSaccharomyces cerevisiaeand wine fermentation

Effect of Calcium Polysulfide Applications on Severity of Cocoa Pod Rot (Phytophthora palmivora Butl.) and Fungal Diversity

Kinetics of jack bean urease inhibition by 2,3-dichloro-1,4-naphthoquinone. Elucidation of the mechanism: redox cycling and sulfhydryl arylation

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