Chemistry of Gold(III) Complexes with Nitrogen and Oxygen Ligands

Cinellu, Maria Agostina

doi:10.1002/9783527626724.ch2

Cited by 5 publications

(4 citation statements)

References 147 publications

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“…In a continuation of the analogies between Pt(II) and Au(III), neutral Au(III) complexes which could provide coordinatively labile Au(III) cationic species seemed to be a reasonable initial target for establishing Au-based C−H bond activation systems. Of the myriad of potentially fruitful systems, our previous positive experience with cationic, methane-activating diimine Pt(II) compounds led us to choose N-ligated Au(III) complexes as our starting point, particularly since a range of Au(III) compounds bearing nitrogen-based ligands are known . Of the potential candidates, anionic β-diketiminato ligands, one of the most widely used classes of nitrogen-donor ligands in organometallic chemistry, were particularly intriguing.…”

Section: Introductionmentioning

confidence: 99%

(β-Diketiminato)dimethylgold(III): Synthesis, Structure, and Reactivity

et al. 2010

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The reaction between [Me 2 AuCl] 2 and the lithium salt of a β-diketimine, [HC{C(Me)N(C 6 H 3 -2, 6-Me 2 )} 2 Li], yields the neutral Au(III) compound [HC{C(Me)N(C 6 H 3 -2,6-Me 2 )} 2 AuMe 2 ] (1). Compound 1 reacts with 1 equiv of triflic acid (HOTf) at -78 °C to provide the cationic AuTreatment of 1 with 2 equiv of HOTf results in the displacement of Me 2 AuOTf and formation of the β-diketiminato triflate salt [HC{C(Me)NH(C 6 H 3 -2,6-Me 2 )} 2 ][OTf] (3). Compound 1 reacts with I 2 to yield the cation [HC(I)-{C(Me)N(C 6 H 3 -2,6-Me 2 )} 2 AuMe 2 ] þ , which is isolated as the triflate salt [HC(I){C(Me)N(C 6 H 3 -2,6-Me 2 )} 2 AuMe 2 ][OTf] ( 4). The reaction of 1 with (PPh 3 )AuCl in the presence of AgOTf provides [HC(AuPPh 3 ){C(Me)N(C 6 H 3 -2,6-Me 2 )} 2 AuMe 2 ][OTf] (5). Molecular structures of 1, 4, and 5 were elucidated by single-crystal X-ray diffraction experiments; that of 4 was additionally confirmed by quantum-chemical calculations. The reactivity experiments indicate that the methine carbon in the β-diketiminato unit of 1 is the exclusive site of electrophilic attack, while the Au-C bonds are not perturbed.

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Section: Introductionmentioning

confidence: 99%

(β-Diketiminato)dimethylgold(III): Synthesis, Structure, and Reactivity

et al. 2010

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“…However, in recent years, new gold(III) compounds were synthesized, characterized, and shown to have appreciable stability under physiological conditions [14]. In order to enhance the stability of the gold(III) center, polydentate ligands, such as polyamines, cyclam, terpyridine, phenanthroline, and dithiocarbamates, were used [13][14][15][16]. Some of these gold(III) complexes displayed in vitro cytotoxicity comparable or even higher than cisplatin toward several human tumor cell lines resistant to cisplatin [11,[16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

A spectroscopic and electrochemical investigation of the oxidation pathway of glycyl-d,l-methionine and its N-acetyl derivative induced by gold(III)

et al. 2011

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“…The chemistry of olefinic complexes of gold has been described in several review articles [96,123]. In most cases these compounds are not stable [94].…”

Section: Olefinic Complexes Of Gold(iii) (Group Iv)mentioning

confidence: 99%