Chemistry of Hydrogen Peroxide Formation and Elimination in Mammalian Cells, and Its Role in Various Pathologies

Andrés, Celia María Curieses; Lastra, José Manuel Pérez de la; Juan, Celia Andrés; Plou, Francisco J.; Pérez‐Lebeña, Eduardo

doi:10.3390/stresses2030019

Cited by 111 publications

(76 citation statements)

References 104 publications

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“…In the next ROS step, • O 2 − is converted to hydrogen peroxide (H 2 O 2 ) by the superoxide dismutase family of enzymes [ 91 ], and in the presence of the enzyme myeloperoxidase MPO and chloride ion, generates hypochlorous acid HOCl [ 92 ], a potent antibacterial agent that is part of the innate immune system’s antimicrobial arsenal. Other potent oxidants involved are peroxynitrite ONOO − (formed by the reaction between the superoxide anion and the nitric oxide • NO) and hydroxyl radical ( • OH, formed by the Fenton or Haber–Weiss reaction or by the decomposition of ONOO − , • NO 2 and • OH).…”

Section: Reactive Oxygen Species and Its Generationmentioning

confidence: 99%

Myeloid-Derived Suppressor Cells in Cancer and COVID-19 as Associated with Oxidative Stress

et al. 2023

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Myeloid-derived suppressor cells MDSCs are a heterogeneous population of cells that expand beyond their physiological regulation during pathologies such as cancer, inflammation, bacterial, and viral infections. Their key feature is their remarkable ability to suppress T cell and natural killer NK cell responses. Certain risk factors for severe COVID-19 disease, such as obesity and diabetes, are associated with oxidative stress. The resulting inflammation and oxidative stress can negatively impact the host. Similarly, cancer cells exhibit a sustained increase in intrinsic ROS generation that maintains the oncogenic phenotype and drives tumor progression. By disrupting endoplasmic reticulum calcium channels, intracellular ROS accumulation can disrupt protein folding and ultimately lead to proteostasis failure. In cancer and COVID-19, MDSCs consist of the same two subtypes (PMN-MSDC and M-MDSC). While the main role of polymorphonuclear MDSCs is to dampen the response of T cells and NK killer cells, they also produce reactive oxygen species ROS and reactive nitrogen species RNS. We here review the origin of MDSCs, their expansion mechanisms, and their suppressive functions in the context of cancer and COVID-19 associated with the presence of superoxide anion •O2− and reactive oxygen species ROS.

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Section: Reactive Oxygen Species and Its Generationmentioning

confidence: 99%

Myeloid-Derived Suppressor Cells in Cancer and COVID-19 as Associated with Oxidative Stress

et al. 2023

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“…Several mechanisms explain the induction of SDF by ROS: direct oxidative damage, lipid peroxidation by-products, and induction of abortive apoptosis. Direct oxidative damage to DNA bases is thought to be inflicted mainly by mitochondria-originated H 2 O 2 , which is able to penetrate the nucleus due to its low molecular weight and lack of electric charge [ 75 , 91 ]. Furthermore, by-products of lipid peroxidation such as MDA and 4-hydroxynonenal (4HNE) have been shown cause DNA damage through the introduction of DNA adducts such as 8OHdG, 1,N6-ethenoadenosine, and 1,N6-ethenoguanosine [ 92 , 93 , 94 ].…”

Section: Role Of Ros In the Pathophysiology Of Male Infertilitymentioning

confidence: 99%

Antioxidant Intervention against Male Infertility: Time to Design Novel Strategies

et al. 2022

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Infertility is a highly prevalent condition, affecting 9–20% of couples worldwide. Among the identifiable causes, the male factor stands out in about half of infertile couples, representing a growing problem. Accordingly, there has been a decline in both global fertility rates and sperm counts in recent years. Remarkably, nearly 80% of cases of male infertility (MI) have no clinically identifiable aetiology. Among the mechanisms likely plausible to account for idiopathic cases, oxidative stress (OS) has currently been increasingly recognized as a key factor in MI, through phenomena such as mitochondrial dysfunction, lipid peroxidation, DNA damage and fragmentation and finally, sperm apoptosis. In addition, elevated reactive oxygen species (ROS) levels in semen are associated with worse reproductive outcomes. However, despite an increasing understanding on the role of OS in the pathophysiology of MI, therapeutic interventions based on antioxidants have not yet provided a consistent benefit for MI, and there is currently no clear consensus on the optimal antioxidant constituents or regimen. Therefore, there is currently no applicable antioxidant treatment against this problem. This review presents an approach aimed at designing an antioxidant strategy based on the particular biological properties of sperm and their relationships with OS.

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“…Even though it is not the most reactive, H 2 O 2 has one of the longest half-lives of all ROS [ 11 ]. It is widely known that an excess of H 2 O 2 in plant cells promotes oxidative stress due to the generation of highly reactive hydroxyl radicals [ 19 ]. In plant cells, H 2 O 2 has two contrasting purposes.…”

Section: Introductionmentioning

confidence: 99%

Early Antioxidative Response to Desiccant-Stimulated Drought Stress in Field-Grown Traditional Wheat Varieties

Dvojković

Plavšin

Novoselović

et al. 2023

Plants

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Extended drought affects the production and quality of wheat (Triticum aestivum L.), one of the world’s most important food crops. Breeding for increased drought resistance is becoming increasingly important due to the rising demand for food production. Four old traditional Croatian wheat cultivars were used in the present study to examine the early antioxidant response of flag leaves to desiccant-stimulated drought stress and to identify drought-tolerant cultivars accordingly. The results indicate that the enzymatic antioxidant system plays the most significant role in the early response of adult wheat plants to drought stress and the removal of excessive H2O2, particularly GPOD and APX. Nada and Dubrava cultivars revealed the strongest activation of the enzymatic defense mechanism, which prevented H2O2 accumulation and lipid peroxidation. Additionally, the Nada cultivar also showed increased synthesis of proline and specific phenolic compounds, which both contribute to the increased stress tolerance. Among the cultivars investigated, cultivar Nada has the broadest genetic base, which may explain why it possesses the ability to activate both enzymatic and non-enzymatic defense mechanisms in an early response to drought stress. This suggests that old traditional wheat cultivars with broad genetic bases can be a valuable source of drought tolerance, which is especially important given the current climate change.

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Chemistry of Hydrogen Peroxide Formation and Elimination in Mammalian Cells, and Its Role in Various Pathologies

Cited by 111 publications

References 104 publications

Myeloid-Derived Suppressor Cells in Cancer and COVID-19 as Associated with Oxidative Stress

Myeloid-Derived Suppressor Cells in Cancer and COVID-19 as Associated with Oxidative Stress

Antioxidant Intervention against Male Infertility: Time to Design Novel Strategies

Early Antioxidative Response to Desiccant-Stimulated Drought Stress in Field-Grown Traditional Wheat Varieties

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