Chemistry of the Nucleotides

Michelson, A.M.

doi:10.1146/annurev.bi.30.070161.001025

Cited by 30 publications

(13 citation statements)

References 58 publications

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“…In human and other mammals, purine nucleotides are synthesized to meet the needs of the organism for the monomeric precursors of nucleic acids and for those other functions (Michelson, 1963).…”

Section: Metabolismmentioning

confidence: 99%

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Toxic effects and DNA transformation

Savkovic-Stevanovic¹

2018

Biochem Biotechnol Res

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In this paper, mutation point in the nucleotides transformations was studied. The major purine and pyrimidine bases were analyzed. Mutation are hereditary changes in genetic information, resulting from spontaneous or xenobiotic induced DNA damage. Point mutation and frame shift mutations were considered. Phosphorylation is the most important in the synthesis of purine and pyrimidine nucleosides and DNA damage. This paper considers impact of toxic effects to phosphorylation reactions modifications.

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Section: Metabolismmentioning

confidence: 99%

“…The term mutation can be applied to point mutations, which are qualitative changes involving one or a few bases within one gene, as well as to larger changes involving parts of chromosome detectable by light microscopy or even whole chromosomes and thus many thousand of genes (Michelson, 1963).…”

Section: Introductionmentioning

confidence: 99%

Toxic effects and DNA transformation

Savkovic-Stevanovic¹

2018

Biochem Biotechnol Res

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“…The transition between the ordered and an unordered state results in a disruption of stacked base pairs. This leads to hyperchromicity as a consequence of the separation of overlapping elec- trons from the heterocyclic bases (22) and can be conveniently monitored by UV absorbance changes at increasing temperatures.…”

Section: Figmentioning

confidence: 99%

A Highly Efficient Method for Long-Chain cDNA Synthesis Using Trehalose and Betaine

Spiess¹,

Ivell²

2002

Analytical Biochemistry

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“…Some nucleosides may precipitate under the acidic conditions used (18). Nucleosides not excluded may have been hydrolyzed to free bases upon hot acid extraction of the silver precipitate (9). Our assays probably estimate free-base cytokinins and any nucleoside cytokinins precipitable by acidic silver nitrate.…”

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confidence: 93%

Evidence for Cytokinin in Bacterial Leaf Nodules of Psychotria punctata (Rubiaceae)

Edwards¹,

LaMotte²

1975

Plant Physiol.

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MATERIALS AND METHODSCytokinin activity based on two bioassays was at least 100-fold higher in Psychotria punctata leaf discs with bacterial nodules than in discs without them. Nodulated discs from young leaves yielded 0.4 to 6 pg of cytokinin (zeatin equivalents) per g fresh weight of leaf tissue, whereas nonnodulated discs from the same leaves yielded 0 to 0.003 pg per g fresh weight. These estimates probably include free-base cytokinins and, if present, any nucleoside cytokinins precipitable by acidic silver nitrate. Cytokinin concentrations in Psychotria leaf nodules appear to be higher than normally found in green leaves of other plants. In 1-butanol-acetic acid-water (12:3:5, v/v), the one peak of activity chromatographed with an RF similar to zeatin's, but both number and identity of the active substance(s) remain unknown. These findings suggest that a cytokinin is produced by bacteria in leaf nodules of P. punctata and that it is involved in the symbiosis.Miehe (10) Torrey (14,15) have found them in a medium in which pure cultures of Rhizobium had grown.The purposes of this investigation were to determine whether leaf nodules of Psychotria punctata contain cytokinin(s), to measure their concentrations, and to compare these concentrations with those in other portions of the same leaves.

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Chemistry of the Nucleotides

Cited by 30 publications

References 58 publications

Toxic effects and DNA transformation

Toxic effects and DNA transformation

A Highly Efficient Method for Long-Chain cDNA Synthesis Using Trehalose and Betaine

Evidence for Cytokinin in Bacterial Leaf Nodules of Psychotria punctata (Rubiaceae)

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