Chemistry of the thiazoles

Review of the synthesis and biological activity of thiazoles

“…These reactions can be carried out for some hours at room temperature or by heating at steam bath (Scheme 9). [24][25][26][27][28] Treatment of 2-chlorobenzothiazole 28 with thiourea 27 gave benzo[d]thiazol-2-yl carbamimidothioate 29 (Scheme 10). [29] 5-Methyl-N-phenylthiazol-2-amine 46 can be organized by intramolecular nucleophilic substitutionreaction of 1-(2-bromoallyl)-3-phenylthiourea 45 (Scheme 16).…”

ChemInform Abstract: Synthesis of Heterocyclic Compounds from o‐Aminobenzenethiol and Ammonium Thiocarbamate.

“…Tcherniac [20] reported the synthesis of 4-methyl-2-thiazolinone (4) and Ganapathi and Venkataraman [21] reported the preparation of ethyl 4-methyl-2-thiazolinone-5-carboxylate (5) and 4-methyl-5-acetyl-2-thiazolinone (6) by the following reactions: If 2 is allowed to dry longer than two hours or comes in contact with metals it decomposes.…”

“…Venkataraman [21] were employed for the synthesis of 4-6. To a stirrcvi solution at "-10' rontaining 84.6 g (0.9 mole) of 2 in water or acetonv water (Table I), 0.8 mole of chloroacetone, ethyl ol-rhloroacetoacrtatl, or 3-chloro-2,4-pentanedione was added in one portion.…”

Selenium heterocycles. XXXII . Synthesis of [1]benzoxepino[3,4‐d]‐thiazole, [1]benzothiepino[3,4‐d]thiazole, [1]benzoxepino[3,4‐d]selenazole, and [1]benzothiepino[3,4‐d]selenazole. four novel heterocycles

“…Reaction of ethyl 2-phenyl-4-methylthiazole-5carboxylate (111) (10) with N-bromosuccinimide gave ethyl 2-phenyl-4-bromomethylthiazole-5-carboxylate (IV). Reaction of the latter with phenol according to the procedure reported previously (1 1) afforded ethyl 2-phenyl-4phenoxymethylthiazole-5-carboxylate (Va).…”