Chemistry of uranium in nonaqueous solution

Gindler, J.E.

doi:10.2172/4261004

Cited by 1 publication

(1 citation statement)

References 41 publications

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“…Concentration of calcium in serum was estimated by Stein et al 23 and serum magnesium concentration was estimated by Gindler's method. 24 Histopathological studies 25 A portion of the liver was cut into 2-3 pieces of approximately 6 mm size and fixed in phosphate buffered 10% formaldehyde solution. After embedding in the paraffin wax, thin sections of 5 µm thickness of liver tissues were cut and stained with Haematoxyllin-Eoisin staining.…”

Section: Estimation Of Electrolytesmentioning

confidence: 99%

Chemo Preventive Effect of Rutin Against N-Nitrosodiethylamine-Induced and Phenobarbital- Promoted Hepatocellular Carcinoma in Wistar Rats

Chandra¹,

Viswanathswamy²

2018

IJPER

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Background: In recent years, a large number of natural compounds have been identified and proved to have a potential cancer chemopreventive importance due to their strong antioxidant and cytotoxic activities. Objective: The present study is designed to investigate the preventive effects of Rutin against N-Nitrosodiethylamine-induced and Phenobarbital-promoted Hepatocellular carcinoma in male wistar rats. Materials and Methods: Twenty-four male wistar rats were divided into four groups (n=6). Group I serve as Control, Group II was induced HCC by DEN (200mg/kg b.wt) followed by phenobarbital (0.05 % w/v), Group III received same as Group II and followed by Rutin (50mg/kg b.wt) and Group IV received Rutin alone at a dose of 50mg/kg b.wt, up to 16 successive weeks. Results: Results observed that there is significant increase in relative liver weight and liver marker enzymes (P<0.001), tumor marker enzymes (AFP, CEA at P<0.001) and also Significant abnormalities were observed in membrane bound enzymes and Electrolytes, whereas the above said alterations were significantly restored in Rutin treated group compared with DEN treated Group. Conclusion: The results of these findings suggested that Rutin can be used as an adjunct to conventional chemopreventive agent, which may provide a novel therapeutic approach to serve as a promising agent for treatment of Hepatocellular carcinoma.

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Section: Estimation Of Electrolytesmentioning

confidence: 99%