Chemistry, pharmacokinetics, pharmacology and recent novel drug delivery systems of paeonol

Adki, Kaveri M.; Kulkarni, Yogesh A.

doi:10.1016/j.lfs.2020.117544

Cited by 75 publications

(44 citation statements)

References 101 publications

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“…Most research has shown that the effective dose range for paeonol cardioprotection is 2.5-100 mg/kg by intragastric or intraperitoneal administration (Yang et al, 2010;Li et al, 2012;Ma et al, 2015;Li H. et al, 2016;Wu et al, 2018). However, recent data indicate that paeonol has higher bioavailability by intranasal and intravenous administration routes in rats compared with the intragastric route (Chen et al, 2010;Adki and Kulkarni, 2020). We therefore investigated the cardioprotective effects of 0.1 and 1 mg/kg paeonol by intravenous administration in rats subjected to myocardial I/R injury.…”

Section: Experimental Groupsmentioning

confidence: 99%

Paeonol Protects Against Myocardial Ischemia/Reperfusion-Induced Injury by Mediating Apoptosis and Autophagy Crosstalk

Tsai

Chen

et al. 2021

Front. Pharmacol.

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Many studies have shown that crosstalk exists between apoptosis and autophagy, despite differences in mechanisms between these processes. Paeonol, a major phenolic compound isolated from Moutan Cortex Radicis, the root bark of Paeonia × suffruticosa Andrews (Paeoniaceae), is widely used in traditional Chinese medicine as an antipyretic, analgesic and anti-inflammatory agent. In this study, we investigated the detailed molecular mechanisms of the crosstalk between apoptosis and autophagy underlying the cardioprotective effects of paeonol in rats subjected to myocardial ischemia/reperfusion (I/R) injury. Myocardial I/R injury was induced by occlusion of the left anterior descending coronary artery (LAD) for 1 h followed by 3 h of reperfusion. Paeonol was intravenously administered 15 min before LAD ligation. We found that paeonol significantly improved cardiac function after myocardial I/R injury and significantly decreased myocardial I/R-induced arrhythmia and mortality. Paeonol also significantly decreased myocardial infarction and plasma LDH activity and Troponin-I levels in carotid blood after I/R. Compared with vehicle treatment, paeonol significantly upregulated Bcl-2 protein expression and significantly downregulated the cleaved forms of caspase-8, caspase-9, caspase-3 and PARP protein expression in the I/R injured myocardium. Myocardial I/R-induced autophagy, including the increase of Beclin-1, p62, LC3-I, and LC3-II protein expression in the myocardium was significantly reversed by paeonol treatment. Paeonol also significantly increased the Bcl-2/Bax and Bcl-2/Beclin-1 ratios in the myocardium after I/R injury. The cardioprotective role of paeonol during I/R injury may be due to its mediation of crosstalk between apoptotic and autophagic signaling pathways, which inhibits apoptosis and autophagic cell death.

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Section: Experimental Groupsmentioning

confidence: 99%

Paeonol Protects Against Myocardial Ischemia/Reperfusion-Induced Injury by Mediating Apoptosis and Autophagy Crosstalk

Tsai

Chen

et al. 2021

Front. Pharmacol.

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“…In recent years, paeonol has been widely used in medical health care and as a food supplement ( 26 ). Although it has several pharmacological benefits against various diseases, paeonol is mainly used for the treatment of atherosclerotic cardiovascular disease ( 27 ), such as myocardial ischemia, myocardial infarction, atherosclerotic stroke, and myocardial ischemia-reperfusion injury ( 28 ).…”

Section: Biological Characteristics Of Paeonia Suffruticosamentioning

confidence: 99%

Paeonol for the Treatment of Atherosclerotic Cardiovascular Disease: A Pharmacological and Mechanistic Overview

et al. 2021

Front. Cardiovasc. Med.

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With improvement in living standards and average life expectancy, atherosclerotic cardiovascular disease incidences and mortality have been increasing annually. Paeonia suffruticosa, a natural herb, has been used for the treatment of atherosclerotic cardiovascular disease for thousands of years in Eastern countries. Paeonol is an active ingredient extracted from Paeonia suffruticosa. Previous studies have extensively explored the clinical benefits of paeonol. However, comprehensive reviews on the cardiovascular protective effects of paeonol have not been conducted. The current review summarizes studies reporting on the protective effects of paeonol on the cardiovascular system. This study includes studies published in the last 10 years. The biological characteristics of Paeonia suffruticosa, pharmacological mechanisms of paeonol, and its toxicological and pharmacokinetic characteristics were explored. The findings of this study show that paeonol confers protection against atherosclerotic cardiovascular disease through various mechanisms, including inflammation, platelet aggregation, lipid metabolism, mitochondria damage, endoplasmic reticulum stress, autophagy, and non-coding RNA. Further studies should be conducted to elucidate the cardiovascular benefits of paeonol.

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“…Dendrimers are versatile and biocompatible polymers, composed of hyperbranched molecules with various functional groups on their surface. Features such as versatility, water solubility, and internal cavities make them useful for formulation and nanoconstruction in drug delivery [ 40 ]. Janus amphiphilic dendrimers formed micelles suitable for encapsulating camptothecin in therapy against the hepatitis C virus.…”

Section: Materials With Antiviral Activitymentioning

confidence: 99%

Polymeric surfaces with biocidal action: challenges imposed by the SARS-CoV-2, technologies employed, and future perspectives

Castro

Costa

2021

J Polym Res

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The COVID-19 pandemic has demonstrated that hygiene habits reduce the spread of the SARS-CoV-2 virus on contaminated surfaces. In this context, compounds with biocidal properties can act as surface coatings, especially in hospital environments, a source of pathogenic microorganisms. Therefore, the purpose of this review was to report an overview of recent studies with biocidal agents, focusing on polymeric surface modification. Methods such as direct incorporation, direct deposition, and chemical deposition of the microbial agent on the polymeric surface and surface modification without a microbial agent were discussed. Despite several studies in the literature, antimicrobial materials still face challenges such as commercialization, material stability in post-processing, and guarantee of long cycles. Moreover, effectiveness, toxicity, and final cost must be balanced. We also discussed the concept of antiviral activity and the action mode of the materials. Inorganic, organic materials, nanocomposites, and biopolymers have been addressed as viral inhibitors of several diseases. Lastly, we explored the functional validation of polymeric surface through characterization techniques.

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Chemistry, pharmacokinetics, pharmacology and recent novel drug delivery systems of paeonol

Cited by 75 publications

References 101 publications

Paeonol Protects Against Myocardial Ischemia/Reperfusion-Induced Injury by Mediating Apoptosis and Autophagy Crosstalk

Paeonol Protects Against Myocardial Ischemia/Reperfusion-Induced Injury by Mediating Apoptosis and Autophagy Crosstalk

Paeonol for the Treatment of Atherosclerotic Cardiovascular Disease: A Pharmacological and Mechanistic Overview

Polymeric surfaces with biocidal action: challenges imposed by the SARS-CoV-2, technologies employed, and future perspectives

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