The purpose of this study is to develop a natural science learning game oriented toward local Papuan culture for grade IV elementary school students that is feasible and effective. This research uses a qualitative approach with research and development (R&D) research methods with the Lee and Owen development model. The results of the formative evaluation showed an average feasibility test of 3.94 for material experts, learning design experts, and media experts, with good conclusions; one-to-one evaluations,with students obtaining an average of 3.05 with good conclusions;small group evaluations, with an average of 3.43 with very good conclusions; and field trial evaluations, withan average score of 3.61 with a very good conclusion. Therefore, it was concluded that the science learning game oriented toward local Papuan culture for Grade IV elementary school students was very good. The effectiveness of science learning game development oriented toward local Papuan culture was tested through t tests. The results show a Sig. (2-tailed) value of 0.000 < 0.05, so there is a significant difference between science learning outcomes in the pretest and posttest data, so it can be concluded that science learning games oriented toward local Papuan culture are effective in improving the learning outcomes of Grade IV elementary school students.