Chemo diversity of ginger-a potent crop in Manipur and its acetylcholinesterase (AChE) inhibitory potential

Chaudhary, Sushil Kumar; Keithellakpam, Ojit Singh; Lalvenhimi, Salem; Chanda, Joydeb; Bhowmick, Shovonlal; Kar, Amit; Nameirakpam, Bunindro; Bhardwaj, Pardeep Kumar; Sharma, Nanaocha; Rajashekar, Yallappa; Devi, Sarangthem Indira

doi:10.1016/j.bse.2022.104560

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…The 1,8‐cineole interaction with the AChE enzyme was determined as −4.66 kcal/mol [28] . The interactions of linalool with the AChE enzyme were examined as −5.16 kcal/mol, [29] −5.50 kcal/mol, [30] and −6.00 kcal/mol [31] . The interaction of linalool with the urease enzyme was examined as −51.22 [32] .…”

Section: Resultsmentioning

confidence: 99%

“…[28] The interactions of linalool with the AChE enzyme were examined as À 5.16 kcal/mol, [29] À 5.50 kcal/mol, [30] and À 6.00 kcal/mol. [31] The interaction of linalool with the urease enzyme was examined as À 51.22. [32] The binding affinities of the interaction of phytol with the tyrosinase enzyme were determined as À 4.70 kcal/mol.…”

Section: Molecular Dockingsmentioning

confidence: 99%

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Chemical Constituents and Bioactivities of Nepeta Taxa Essential Oils from Turkey: Principal Component Analysis, Molecular Docking Study, Molecular Dynamics, MM‐PBSA and Drug‐Likeness Estimation

Yenigun,

Basar,

Gul

et al. 2024

ChemistrySelect

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Nepeta taxa are popular plants and sources of traditional Turkish medicine. Chemical constituents in the essential oils (EOs) hydrodistilled from above‐ground parts of Nepeta aristata (NA), N. baytopii (NB), N. italica (NI), N. nuda (NN), and N. stenantha (NS) were determined using GC‐MS. The pharmacological activities of EOs, such as biological activities, were evaluated in vitro. DNA protection activities of NS‐EO were found to be the most effective. The NA‐EO, NI‐EO, and NS‐EO were more potent urease inhibitors, while the NS‐EO exhibited potent AChE inhibitors. Their molecular docking, molecular dynamics and enzyme inhibition results were compatible with the major components. Furthermore, MolDock and binding affinity results were found to be high. Moreover, AChE‐tau‐cadinol, BChE‐tau‐cadinol and tyrosinase‐Caryophyllene oxide complexes showed stability when simulated for 100 ns, with high MM‐PBSA energy values. In addition, the main components′ pharmacokinetic properties were observed to be effective. The present study showed that EOs may be valuable natural products for future pharmacological research, food, and the cosmetic industry according to in vitro and in silico values.

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Section: Resultsmentioning

confidence: 99%

Section: Molecular Dockingsmentioning

confidence: 99%

Chemical Constituents and Bioactivities of Nepeta Taxa Essential Oils from Turkey: Principal Component Analysis, Molecular Docking Study, Molecular Dynamics, MM‐PBSA and Drug‐Likeness Estimation

Yenigun,

Basar,

Gul

et al. 2024

ChemistrySelect

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Antidiabetic and Antioxidant Activities of Indian Bay Leaf (Cinnamomum tamala (Buch.‐Ham.) T. Nees & Eberm.) Essential Oils Collected from Meghalaya

Kumar Chaudhary,

Kharlyngdoh,

Shukla

et al. 2024

Chemistry & Biodiversity

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The current work investigates the chemodiversity, in vitro antioxidant, α‐amylase and α‐glucosidase inhibitory potential of Cinnamomum tamala leaf essential oil collected from different localities of East Khasi Hills District of Meghalaya, India. Gas chromatography‐mass spectrometry (GC‐MS) analysis of all the extracted leaf essential oils facilitated the identification of several compounds in a variable range along with eugenol as the major component (74.79‐95.12 %). CT8 exhibited the highest antioxidant activity (IC50 = 11.23 ± 0.27 μg/mL for DPPH and IC50 = 21.54 ± 0.37 μg/mL for ABTS) among all the evaluated EO compounds. The results showed that the FRAP and ORAC values for CT8 were 83.26 ± 1.92 µM trolox/g oil and 70.29 ± 1.90 ascorbic acid equivalents (AAE)/g of oil. α‐amylase and α‐glucosidase inhibition were highest in sample CT8 with IC50 values of 3.62 ± 0.42 µg/mL and 16.29 ± 0.32 µg/mL respectively. Caryophyllene, cyclohexene, 1, 5, 5‐trimethyl‐6‐(2‐propenylidene), germacrene D and eugenol showed strong binding potential toward α‐amylase and α‐glucosidase. It concluded that the chemodiversity and antidiabetic potential of C. tamla oil from Khasi Hills have never been studied. It can be taken as a dietary supplement as an antioxidant and antidiabetic to control blood glucose.

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Chemo diversity of ginger-a potent crop in Manipur and its acetylcholinesterase (AChE) inhibitory potential

Cited by 2 publications

References 34 publications

Chemical Constituents and Bioactivities of Nepeta Taxa Essential Oils from Turkey: Principal Component Analysis, Molecular Docking Study, Molecular Dynamics, MM‐PBSA and Drug‐Likeness Estimation

Chemical Constituents and Bioactivities of Nepeta Taxa Essential Oils from Turkey: Principal Component Analysis, Molecular Docking Study, Molecular Dynamics, MM‐PBSA and Drug‐Likeness Estimation

Antidiabetic and Antioxidant Activities of Indian Bay Leaf (Cinnamomum tamala (Buch.‐Ham.) T. Nees & Eberm.) Essential Oils Collected from Meghalaya

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