Chemo-embolization of experimental liver metastases. Part I: distribution of biodegradable microspheres of different sizes in an animal model for the locoregional therapy

Bastian, Patrick J.; Bartkowski, R; Köhler, Hans; Kissel, Thomas

doi:10.1016/s0939-6411(98)00047-2

Cited by 66 publications

(28 citation statements)

References 27 publications

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“…Too small microspheres are easily removed by mononuclear macrophage or result in embolization in nontargeted organs, whereas too large ones are trapped in lateral circulation branches after embolization with a poor long‐term effect. A mean particle diameter of at least 40 μm is required for embolization 6. In our experiments, the average diameter of collected microparticles was around 80 μm with a stir rate of approximately 250 rpm, which fits the use of embolization.…”

Section: Resultssupporting

confidence: 61%

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Preparation and drug release characteristics of pingyangmycin‐loaded dextran cross‐linked gelatin microspheres for embolization therapy

Zhang

et al. 2005

J Biomed Mater Res

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Gelatin microspheres (GMs) containing Pingyangmycin hydrochloride were prepared for the interventional embolization by a double-phase emulsified thermal gelation method using oxidized dextran (ox-dex) as the cross-linking agent. The average diameter of the microspheres was 82 microm with 74% ranging from 50-200 microm. Drug content and the characteristics of drug release in vitro and in vivo were evaluated using UV-spectroscopy and HPLC, respectively. The prepared microspheres showed a rather high percentage of encapsulation ranging from 85 to 88% and drug content at 7.2%. The results of in vitro experiments showed that about 65.5% of the total amount of the encapsulated drug was released after 6 h at 37 degrees C. Experiments conducted through artery perfusion and artery embolization in rabbits revealed that the local drug concentration was significantly higher than the systemic blood-drug concentration, with a high level of local drug concentration maintained for more than 120 min after artery embolization with the Pingyangmycin-loaded ox-dex-GMs. The results indicated that the external carotid artery embolization with Pingyangmycin-loaded ox-dex-GMs at reduced dosages prolonged the local drug concentration at a higher level, and could achieve the purpose of a localized targeting tumor therapy. Compared with other embolization materials, ox-dex-GMs are an excellent alternative interventional embolization material for the treatment of head and neck tumors.

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Section: Resultssupporting

confidence: 61%

“…In the past, embolization and chemotherapy have been combined to treat malignant tumor, mostly incorporating chemotherapeutics perfused or injected into the tumor. Nowadays, more and more attention has been focused on the study of embolic agents loaded with chemotherapeutic medicine 6…”

Section: Introductionmentioning

confidence: 99%

Preparation and drug release characteristics of pingyangmycin‐loaded dextran cross‐linked gelatin microspheres for embolization therapy

Zhang

et al. 2005

J Biomed Mater Res

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“…To obtain therapeutic embolic effects in rats, the microsphere size should be adjusted to the diameters of the terminal arterioles (10-50 m) and capillaries (8-10 m) in the rat liver [21]. It was also reported that a mean diameter of 40 m was required for the embolization of liver cancer in a rat model; particles with a mean diameter less than 40 m were distributed to other organs, such as the lung and spleen [22]. In this investigation, PLGA MSs with a 26-m mean diameter (7-48 m entire size range) were prepared (Table S1 and Fig.…”

Section: Discussionmentioning

confidence: 99%

Doxorubicin-loaded poly(lactic-co-glycolic acid) microspheres prepared using the solid-in-oil-in-water method for the transarterial chemoembolization of a liver tumor

Choi

Park

Baek

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…The latter include venous circulation which can result in spillage to the lungs, or the collateral arterial system in which stray emboli could be transported to structures such as the brain [32]. Particles which have been used in liver embolization vary between 10 and 50 lm [30,[33][34][35][36]. However, when such particles were used in a head and neck tumour 50 % of 19 lm diameter spheres were found in the lung, whereas less than 5 % of particles in the 40-66 lm range were detected in the lungs.…”

Section: Discussionmentioning

confidence: 99%

Synthesis and characterization of polystyrene embolization particles doped with tantalum oxide nanoparticles for X-ray contrast

Morrison

Thompson

Bird

et al. 2015

J Mater Sci: Mater Med

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Radiopaque and fluorescent embolic particles have been synthesized and characterised to match the size of vasculature found in tumours to ensure effective occlusion of the vessels. A literature search showed that the majority of vessels surrounding a tumour were less than 50 µm and therefore polydispersed polystyrene particles with a peak size of 50 µm have been synthesised. The embolic particles contain 5-8 nm amorphous tantalum oxide nanoparticles which provide X-ray contrast. Embolic particles containing up to 9.4 wt% tantalum oxide were prepared and showed significant contrast compared to the undoped polystyrene particles. The X-ray contrast of the embolic particles was shown to be linear (R(2) = 0.9) with respect to the concentration of incorporated tantalum nanoparticles. A model was developed which showed that seventy-five 50 µm embolic particles containing 10% tantalum oxide could provide the same contrast as 5 cm of bone. Therefore, the synthesized particles would provide sufficient X-ray contrast to enable visualisation within a tumour.

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Chemo-embolization of experimental liver metastases. Part I: distribution of biodegradable microspheres of different sizes in an animal model for the locoregional therapy

Cited by 66 publications

References 27 publications

Preparation and drug release characteristics of pingyangmycin‐loaded dextran cross‐linked gelatin microspheres for embolization therapy

Preparation and drug release characteristics of pingyangmycin‐loaded dextran cross‐linked gelatin microspheres for embolization therapy

Doxorubicin-loaded poly(lactic-co-glycolic acid) microspheres prepared using the solid-in-oil-in-water method for the transarterial chemoembolization of a liver tumor

Synthesis and characterization of polystyrene embolization particles doped with tantalum oxide nanoparticles for X-ray contrast

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