Chemo-enzymatic synthesis of 3′-O,4′-C-methylene-linked α-l-arabinonucleosides

Abstract

Biocatalytic methodology has been developed for the efficient and environment friendly synthesis of 3′-O,4′-C-methylene-linked α-l-arabinonucleosides.

Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor

“…In the past few years, several works about the enzyme-catalyzed synthesis of uridine esters were reported. [29][30][31][32][33][34][35][36] Some lipase such as CAL-B 22 and pseudomonas cepacia lipase 29 have been applied to the synthesis of uridine esters, but it requires a longer reaction time (24 h) to achieve the desired result. Flow chemistry especially catalyst/substrate conditions in continuous-ow systems can increase the reactivity and selectivity.…”