Chemo-photothermal therapeutic effect of chitosan-gelatin hydrogels containing methotrexate and melanin on a collagen-induced arthritis mouse model

Kim, Min Ah.; Shin, So Ryung; Kim, Hyeon Jin; Lee, Jung Sick; Lee, Chang-Moon

doi:10.1016/j.ijbiomac.2022.07.227

Cited by 11 publications

(3 citation statements)

References 34 publications

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“…Furthermore, chitosan/gelatin/βGP-melanin-methotrexate hydrogel exhibits a rapid release of methotrexate instantaneously, when it is injected directly into the paw joint of collagen-induced arthritis mice, followed by irradiation. Conclusively, treated joints of mice are similar to normal joints under Micro-CT analysis [ 209 ].…”

Section: Pharmaceutical and Biomedical Applications Of Chitosan-based...mentioning

confidence: 99%

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Taokaew

Kaewkong

Kriangkrai

2023

Gels

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Chitosan is a promising naturally derived polysaccharide to be used in hydrogel forms for pharmaceutical and biomedical applications. The multifunctional chitosan-based hydrogels have attractive properties such as the ability to encapsulate, carry, and release the drug, biocompatibility, biodegradability, and non-immunogenicity. In this review, the advanced functions of the chitosan-based hydrogels are summarized, with emphasis on fabrications and resultant properties reported in literature from the recent decade. The recent progress in the applications of drug delivery, tissue engineering, disease treatments, and biosensors are reviewed. Current challenges and future development direction of the chitosan-based hydrogels for pharmaceutical and biomedical applications are prospected.

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Section: Pharmaceutical and Biomedical Applications Of Chitosan-based...mentioning

confidence: 99%

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Taokaew

Kaewkong

Kriangkrai

2023

Gels

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“…Currently, the most prominent phototherapy strategy for treating RA involves utilizing PTT or PDT to target and eliminate pathogenic cells in the affected joints, thereby reducing the expression of inflammatory factors and interfering with synovial hyperplasia, as well as bone and cartilage destruction [ 155 , 156 ]. However, the non-specific nature of heat and ROS generated by PTT and PDT poses a challenge in achieving targeted therapy.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Phototherapy techniques for the management of musculoskeletal disorders: strategies and recent advances

Zhang,

Wang,

Xue

et al. 2023

Biomater Res

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Musculoskeletal disorders (MSDs), which include a range of pathologies affecting bones, cartilage, muscles, tendons, and ligaments, account for a significant portion of the global burden of disease. While pharmaceutical and surgical interventions represent conventional approaches for treating MSDs, their efficacy is constrained and frequently accompanied by adverse reactions. Considering the rising incidence of MSDs, there is an urgent demand for effective treatment modalities to alter the current landscape. Phototherapy, as a controllable and non-invasive technique, has been shown to directly regulate bone, cartilage, and muscle regeneration by modulating cellular behavior. Moreover, phototherapy presents controlled ablation of tumor cells, bacteria, and aberrantly activated inflammatory cells, demonstrating therapeutic potential in conditions such as bone tumors, bone infection, and arthritis. By constructing light-responsive nanosystems, controlled drug delivery can be achieved to enable precise treatment of MSDs. Notably, various phototherapy nanoplatforms with integrated imaging capabilities have been utilized for early diagnosis, guided therapy, and prognostic assessment of MSDs, further improving the management of these disorders. This review provides a comprehensive overview of the strategies and recent advances in the application of phototherapy for the treatment of MSDs, discusses the challenges and prospects of phototherapy, and aims to promote further research and application of phototherapy techniques. Graphical Abstract

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“…For example, more and more researchers have modified the surface of MOFs in the synthesis process to improve the sensitivity and specificity of MOFs in tumor diagnosis and treatment in combination with different tumor-targeting or treatment mechanisms. These multifaceted composites encompass various therapeutic modalities, including photodynamic therapy, 58 photothermal effects 59 and immunogenic cell death within the scope of tumor treatment. 60–62 Such multi-dimensional interventions have the potential to improve prognosis and increase survival for affected individuals.…”

Section: Introductionmentioning

confidence: 99%

Advancements and Challenges in the Application of Metal-Organic Framework (MOF) Nanocomposites for Tumor Diagnosis and Treatment

Hou,

Zhu,

Ban

et al. 2024

IJN

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Chemo-photothermal therapeutic effect of chitosan-gelatin hydrogels containing methotrexate and melanin on a collagen-induced arthritis mouse model

Cited by 11 publications

References 34 publications

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Phototherapy techniques for the management of musculoskeletal disorders: strategies and recent advances

Advancements and Challenges in the Application of Metal-Organic Framework (MOF) Nanocomposites for Tumor Diagnosis and Treatment

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