Chemo-radiotherapy versus radiotherapy alone for nasopharyngeal carcinoma: A meta-analysis of 78 randomized controlled trials (RCTs) from English and non-English databases

Thephamongkhol, Kullathorn; Zhou, J.; Browman, G; Wong, Raimond; Chan, Jackson; Zeng, Yi; Thabane, L.; Hodson, I.; Oliver, Thomas R.

doi:10.1200/jco.2004.22.14_suppl.5522

Cited by 11 publications

(9 citation statements)

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“…Similarly, no benefit was reported in an Asian trial that randomized 157 patients with Stage IV NPC to undergo RT, with or without 9 cycles of adjuvant cisplatin, 5‐FU, and leucovorin 35. In light of the lack of benefit with adjuvant chemotherapy as reported in the 2 × 2 factorial study by Kwong et al8 and the meta‐analysis performed by Thephamongkhol et al,5 it is possible that the concurrent component as opposed to the adjuvant component of the Intergroup 0099 study accounted for the observed survival benefit. Poor patient compliance to adjuvant chemotherapy also limits its broader application.…”

Section: The Role Of Chemotherapy In Locoregionally Advanced Npc–how mentioning

confidence: 97%

“…This analysis compared the impact on patient survival of adding chemotherapy to RT at any sequence. Published studies from both English and non‐English databases were selected according to the quality of the randomization procedure, the use of intention‐to‐treat analysis, and the completeness of follow‐up 5. Presented in an abstract form, this analysis found that concurrent chemoradiation improves 5‐year overall survival by an odds ratio of 0.68 (95% confidence interval [95% CI], 0.46–0.99), and that concurrent chemoradiation followed by adjuvant chemotherapy improves the 5‐year disease‐free and overall survival rates with an odds ratio of 0.30 (95% CI, 0.16–0.55) and 0.30 (95% CI, 0.17–0.53), respectively.…”

Section: The Role Of Chemotherapy In Locoregionally Advanced Npc–how mentioning

confidence: 99%

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Frontotemporal and dopaminergic control of idea generation and creative drive

Flaherty

2005

J of Comparative Neurology

343

209

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This article presents a three-factor anatomical model of human idea generation and creative drive, focusing on interactions between the temporal lobes, frontal lobes, and limbic system. Evidence is drawn from functional imaging, drug studies, and lesion analysis. Temporal lobe changes, as in hypergraphia, often increase idea generation, sometimes at the expense of quality. Frontal lobe deficits may decrease idea generation, in part because of rigid judgments about an idea's worth. These phenomena are clearest in verbal creativity, and roughly parallel the pressured communication of temporal lobe epilepsy, mania, and Wernicke's aphasia-compared to the sparse speech and cognitive inflexibility of depression, Broca's aphasia, and other frontal lobe lesions. The phenomena also shape non-linguistic creativity, as in that of frontotemporal dementia. The appropriate balance between frontal and temporal activity is mediated by mutually inhibitory corticocortical interactions. Mesolimbic dopamine influences novelty seeking and creative drive. Dopamine agonists and antagonists have opposite effects on goal-directed behavior and hallucinations. Creative drive is not identical to skill-the latter depends more on neocortical association areas. However, drive correlates better with successful creative output than skill does. Traditional neuroscientific models of creativity, such as the left brain - right brain hemispheric model, emphasize skills primarily, and stress art and musical skill at the expense of language and mathematics. The three-factor model proposed here predicts findings in a broad range of normal and pathological states and can be tested in many experimental paradigms.

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Section: The Role Of Chemotherapy In Locoregionally Advanced Npc–how mentioning

confidence: 97%

Section: The Role Of Chemotherapy In Locoregionally Advanced Npc–how mentioning

confidence: 99%

Frontotemporal and dopaminergic control of idea generation and creative drive

Flaherty

2005

J of Comparative Neurology

343

209

View full text Add to dashboard Cite

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“…Huncharek and Thephamongkhol [25][26] reported that the survival benefit was predominantly observed with CCRT using platinum-based agents; the benefit of induction and adjuvant CT remains unclear.…”

Section: How To Best Incorporate Chemotherapy With Radiotherapy?mentioning

confidence: 99%

Concurrent chemoradiotherapy in the management of advanced nasopharyngeal carcinoma: Current status

2009

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Nasopharyngeal carcinoma (NPC) differs from other head and neck cancers in its epidemiology, natural behavior and, particularly, in the therapeutic considerations. In addition, NPC is responsive to both chemotherapy and radiotherapy (RT). This article reviews the recent advances in concurrent chemoradiotherapy (CCRT) for NPC. To identify the studies mentioned in this article, we searched the MEDLINE database, and abstracts of selected conference proceedings (up to 2008) using the key words 'nasopharyngeal carcinoma,' 'advanced,' 'radiotherapy,' and 'concurrent chemotherapy.' Eight randomized clinical trials of CCRT in NPC have been reported in the English literature. These trials can be classified according to the timing of the chemotherapy, which was given either concurrently with RT (in three trials) or concurrently with radiotherapy and adjuvant after the and of concurrent chemoradiotherapy (in five trials). There have also been four meta-analyses addressing the value and scheduling of chemotherapy in the curative treatment of NPC. This article reviews the recent literature and the pertinent issues concerning the role of CCRT in the treatment of patients with locoregionally advanced NPC.

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“…It, however, has a high incidence in a few well-defined populations, including natives of southern China, Southeast Asia, the Arctic, and the Middle East/North Africa (1–3). Concurrent chemoradiotherapy is considered as a standard treatment approach for locoregionally advanced NPC and platinum-based regimen is thought to be one of the best protocols by meta-analysis (4, 5). However, meta-analysis of individual patient data from eight randomized trials containing 1753 patients showed that, compared to radiotherapy alone, cisplatin-based concurrent chemoradiotherapy improved 5-year disease-free survival by only 10% (52% vs. 42%) in locaoregionally advanced NPC (4).…”

Section: Introductionmentioning

confidence: 99%

Overexpression of Asparagine Synthetase and Matrix Metalloproteinase 19 Confers Cisplatin Sensitivity in Nasopharyngeal Carcinoma Cells

Liu

Dong

Liu

et al. 2013

Molecular Cancer Therapeutics

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Platinum-based concurrent chemo-radiotherapy is considered a standard treatment approach for locoregionally advanced nasopharyngeal carcinoma (NPC). However, only a minority of patients benefit from this treatment regimen compared to radiotherapy alone. Identification of a set of molecular markers predicting sensitivity of platinum-based chemotherapy may contribute to personalized treatment of NPC patients for better clinical outcome with less toxicity. Previously, we generated a cisplain sensitive NPC cell line, S16, by clonal selection from CNE-2 cells and found that eIF3a is up-regulated and contributes to cisplatin sensitivity by down-regulating the synthesis of NER proteins. In this study, we conducted a gene expression profiling analysis and found three other genes, asparagine synthetase (ASNS), choriogonadotropin α subunit (CGA), and matrix metalloproteinase 19 (MMP19), that are up-regulated in the cisplatin-sensitive S16 cells compared with the CNE-2 cells. However, only ASNS and MMP19, but not CGA, contributes to cisplatin sensitivity by potentiating cisplatin-induced DNA damage and apoptosis. Thus, ASNS and MMP19, along with eIF3a, are sensitivity factors for cisplatin treatment and may serve as potential candidate molecular markers for predicting cisplatin sensitivity of advanced nasopharyngeal carcinoma.

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Chemo-radiotherapy versus radiotherapy alone for nasopharyngeal carcinoma: A meta-analysis of 78 randomized controlled trials (RCTs) from English and non-English databases

Cited by 11 publications

References 0 publications

Frontotemporal and dopaminergic control of idea generation and creative drive

Frontotemporal and dopaminergic control of idea generation and creative drive

Concurrent chemoradiotherapy in the management of advanced nasopharyngeal carcinoma: Current status

Overexpression of Asparagine Synthetase and Matrix Metalloproteinase 19 Confers Cisplatin Sensitivity in Nasopharyngeal Carcinoma Cells

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