Chemo-sensitizing activity of natural cadinanes from Heterotheca inuloides in human uterine sarcoma cells and their in silico interaction with ABC transporters

Rodríguez‐Chávez, José Luis; Méndez-Cuesta, Carlos A.; Ramírez‐Ápan, Teresa; Egas, Verónica; Ávila, José Luis Sánchez; Neira-González, Adriana; Hernández, Tzasná; Espinosa‐García, Francisco J.; Delgado, Guillermo

doi:10.1016/j.bioorg.2019.103091

Cited by 9 publications

(1 citation statement)

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“…Drug efflux, facilitated by membrane transport proteins, is associated with the development of MDR in tumor cells [95]. Overexpression of ATP-binding cassette (ABC) membrane transport proteins has been considered the leading contributor to resistance and chemotherapy failure in several types of cancer [96][97][98].…”

Section: Targets Of Natural Products In Cancer Chemo-resistancementioning

confidence: 99%

Targeting Drug Chemo-Resistance in Cancer Using Natural Products

et al. 2021

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Cancer is one of the leading causes of death globally. The development of drug resistance is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms to reduce the therapeutic effects of anticancer drugs, thereby causing chemotherapy failure. Natural products are accessible, inexpensive, and less toxic sources of chemotherapeutic agents. Additionally, they have multiple mechanisms of action to inhibit various targets involved in the development of drug resistance. In this review, we have summarized the basic research and clinical applications of natural products as possible inhibitors for drug resistance in cancer. The molecular targets and the mechanisms of action of each natural product are also explained. Diverse drug resistance biomarkers were sensitive to natural products. P-glycoprotein and breast cancer resistance protein can be targeted by a large number of natural products. On the other hand, protein kinase C and topoisomerases were less sensitive to most of the studied natural products. The studies discussed in this review will provide a solid ground for scientists to explore the possible use of natural products in combination anticancer therapies to overcome drug resistance by targeting multiple drug resistance mechanisms.

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