2023
DOI: 10.1101/2023.02.03.526974
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Chemo-sEVs release in cisplatin-resistance ovarian cancer cells are regulated by the lysosomal function

Abstract: Ovarian cancer (OvCa) is an aggressive disease usually treated with cisplatin (CDDP)-based therapy. However, among the different types of cancers treated with CDDP, OvCa commonly develops chemoresistance to this treatment. The small extracellular vesicles (sEVs) play a central role in chemoresistance. In response to chemotherapy, resistant cells secrete sEVs named chemo-sEVs characterized by specific cargo landscape content involved in the transfer of chemoresistance to recipient cells. sEVs encompass a variet… Show more

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“…We also thank Dr Ana L. Riveros Salvatierra (FONDEQUIP EQM160157, School of Chemical and Pharmaceutical Sciences, University of Chile) for her technical assistance in particle analysis determination. The main research was performed in the Doctoral Thesis of Dr Cristóbal Cerda‐Troncoso titled ‘Decoding adaptive cellular mechanisms of cisplatin chemoresistance in ovarian cancer cells’, presented in Abril of 2022 (Cerda‐Troncoso, 2022 ). This research was funded by Fondo Nacional de Desarrollo Cientifico y Tecnologico de Chile (FONDECYT) grants numbers 1171649 and 1211261 (Patricia V. Burgos), 1190928 and 1230983 (Manuel Varas‐Godoy); ANID/BASAL/FB210008 (Manuel Varas‐Godoy and Patricia V. Burgos); FONDECYT postdoctoral fellowship 3220485 (Viviana A. Cavieres) 3200825 (Francisca Álvarez‐Astudillo) and; Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias (FONDAP) grant 15130011 (Manuel Varas‐Godoy); ANID doctoral fellowship 21230341 (Belén Gaete‐Ramírez); and Vicerrectoria de Investigación y Doctorados, Universidad San Sebastián for PhD scholarship (Cristóbal Cerda‐Troncoso).…”
Section: Acknowledgementsmentioning
confidence: 99%
“…We also thank Dr Ana L. Riveros Salvatierra (FONDEQUIP EQM160157, School of Chemical and Pharmaceutical Sciences, University of Chile) for her technical assistance in particle analysis determination. The main research was performed in the Doctoral Thesis of Dr Cristóbal Cerda‐Troncoso titled ‘Decoding adaptive cellular mechanisms of cisplatin chemoresistance in ovarian cancer cells’, presented in Abril of 2022 (Cerda‐Troncoso, 2022 ). This research was funded by Fondo Nacional de Desarrollo Cientifico y Tecnologico de Chile (FONDECYT) grants numbers 1171649 and 1211261 (Patricia V. Burgos), 1190928 and 1230983 (Manuel Varas‐Godoy); ANID/BASAL/FB210008 (Manuel Varas‐Godoy and Patricia V. Burgos); FONDECYT postdoctoral fellowship 3220485 (Viviana A. Cavieres) 3200825 (Francisca Álvarez‐Astudillo) and; Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias (FONDAP) grant 15130011 (Manuel Varas‐Godoy); ANID doctoral fellowship 21230341 (Belén Gaete‐Ramírez); and Vicerrectoria de Investigación y Doctorados, Universidad San Sebastián for PhD scholarship (Cristóbal Cerda‐Troncoso).…”
Section: Acknowledgementsmentioning
confidence: 99%