Chemodectoma of the head and neck: Results of treatment in 84 patients

Powell, S.N.; Peters, Nils; Harmer, C.

doi:10.1016/0360-3016(92)90788-j

Cited by 106 publications

(96 citation statements)

References 27 publications

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“…Conventional radiotherapy also involves certain complications, although they are considered of low incidence: 7% for minor complications and 2-3% for more severe complications [8,11,12] . Radionecrosis of the temporal bone or brain, mastoiditis, acute dermatitis, alopecia, mucositis, external otitis, serous otitis media, altered taste, xerostomia, and carcinogenesis have been reported as complications of fractionated radiotherapy [8,10,[13][14][15][16][17][18] . Moreover, fractionated radiotherapy usually requires 20-25 fractions with at least a 40-Gy accumulated dose for a treatment course.…”

Section: Discussionmentioning

confidence: 99%

Gamma Knife Radiosurgery for Glomus Jugulare and Tympanicum

Lee

Pan

et al. 2011

Stereotact Funct Neurosurg

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Objective: To establish the role of gamma knife radiosurgery (GKS) as a treatment strategy for glomus jugulare and tympanicum. Method: A retrospective review of 14 glomus tumors, including 11 glomus jugulare and 3 glomus tympanicum tumors, which were treated by GKS in Taipei Veterans General Hospital from 1993 to 2009, was conducted. Two of these cases had undergone prior surgery with partial tumor resection, and the other 12 cases received primary treatment with GKS after a thorough neuroimaging and cerebral angiography. The tumor volume ranged from 6.5 to 22.1 ml. The maximum dose at the tumor center ranged from 21.6 to 26.3 Gy. All 14 patients were regularly followed up by clinical and radiological evaluations. The median follow-up time was 40.3 months. Results: All 14 patients had significant tumor regression after radiosurgery. The median tumor volume reduction was 34.0% (range 3–79%). Only 1 patient had temporary tumor volume progression (24% increment 6 months post-treatment), accompanied with unilateral facial palsy (from grade III to grade IV) and hearing impairment (from grade I to grade II). The tumor volume of this patient had regressed by 12 months, but facial palsy persisted. The tumor control rate in the series was 100% (n = 14/14), and the preservation rate of cranial nerve function was 92.8% (13/14). There was no complication of lower cranial nerve damage after radiosurgery. Conclusion: GKS appeared to be a good alternative or adjuvant to microsurgical resection in patients who are not amenable to complete surgical eradication, with an excellent tumor control rate and little morbidity after long-term follow-up.

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Section: Discussionmentioning

confidence: 99%

Gamma Knife Radiosurgery for Glomus Jugulare and Tympanicum

Lee

Pan

et al. 2011

Stereotact Funct Neurosurg

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“…With further growth, they involve the lower CNs, leading to speech and swallowing deficits (hoarseness and dysphagia) and sometimes to aspiration (Miller et al 2000, Offergeld et al 2012. A preoperative CN deficit is frequently observed in VPGLs (25-36%) and JTPGLs (39-40%) and less so in CBTs (4-22%) (Powell et al 1992, Netterville et al 1998, Sajid et al 2007, Neskey et al 2011.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…The control rate decreases significantly with time: 95-96% at 5 years and 88-94% at 10 years, but only 73% at 25 years. Diseaserelated mortality after radiotherapy is low (0-5.1%; Cummings et al 1984, Hansen & Thomsen 1988, Powell et al 1992, Verniers et al 1992, Hinerman et al 2001, Chino et al 2009, Huy et al 2009, Lightowlers et al 2010, Suarez et al 2013a). …”

Section: Radiotherapymentioning

confidence: 99%

The management of head-and-neck paragangliomas

Căpățînă

Ntali

Karavitaki

et al. 2013

Endocrine-Related Cancer

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Paragangliomas (PGLs) are tumours originating from neural crest-derived cells situated in the region of the autonomic nervous system ganglia. Head-and-neck PGLs (HNPGLs) originate from the sympathetic and parasympathetic paraganglia, most frequently from the carotid bodies and jugular, tympanic and vagal paraganglia, and are usually non-catecholamine secreting. Familial PGLs are considered to be rare, but recently genetic syndromes including multiple PGLs and/or phaeochromocytomas have been more thoroughly characterised. Nowadays, genetic screening for the genes frequently implicated in both familial and sporadic cases is routinely being recommended. HNPGLs are mostly benign, generally slow-growing tumours. Continuous growth leads to the involvement of adjacent neurovascular structures with increased morbidity rates and treatment-related complications. Optimal management mostly depends on tumour location, local involvement of neurovascular structures, estimated malignancy risk, patient age and general health. Surgery is the only treatment option offering the chance of cure but with significant morbidity rates, so a more conservative approach is usually considered, especially in the more difficult cases. Radiotherapy (fractionated or stereotactic radiosurgery) leads to tumour growth arrest and symptomatic improvement in the short term in many cases, but the longterm consequences are unclear. Early detection is essential in order to increase the chance of cure with a lower morbidity rate. The constant improvement in diagnostic imaging, surgical and radiation techniques has led to a safer management of these tumours, but there are still many therapeutic challenges, and no treatment algorithm has been agreed upon until now. The management of HNPGLs requires a multidisciplinary effort addressing the genetic, surgical, radiotherapeutic, oncological, neurological and endocrinological implications. Further progress in the understanding of their pathogenesis will lead to more effective screening and earlier diagnosis, both critical to successful treatment.

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“…Radiotherapy is suggested for incomplete resection cases and for inoperable Glomus jugulare and rarely for carotid body tumours [9] or in addition to surgery, to control metastasis [10] and for the other hand, for bilateral cases where unilateral X and XII cranial nerves are sacrificed [8]. In our case, a GT was identified inside the mass which was excised by doing a surgical procedure which was performed after initially giving chemotherapy.…”

Section: Discussionmentioning

confidence: 95%

Coexistence of Glomangioma and Yolk Sac Tumour in a Child: A Case Report

Köse

Toy

Günel

et al. 2014

JCDR

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Glomus tumours (GTs) primarily arise from glomus bodies that are located in the dermis layer of skin. However, they can be encountered ectopically in most parts of the body. As a result of researches done in a 17-month-old male patient who prssented to us with complaint of an increasingly growing swelling, he was diagnosed with a yolk sac tumour. Chemotherapy was started and then, he was operated. GT was found inside the tumoural mass. Our patient, who is the first case according to our knowledge, where the concurrence of yolk sac and glomus tumours was reported, has been discussed in the light of literature. CASE REPORTA 17-month-old male patient presented to our hospital with complaint of swelling in hip and inability in sitting. Swelling had occurred about one month ago, it had enlarged increasingly and it had became a condition that prevented him from sitting. During his physical examination, a mass was identified in the sacrococcygeal region. During magnetic resonance imaging (MRI) studies which were done, the mass was seen to invade into the gluteal muscle, posterior to the rectum and it was reported as a teratoma. In thoracic tomogram, a nodular image which was compatible with metastasis in the lower lobe of the right lung was seen. Alpha fetoprotein was 68309 ng/mL.It was diagnosed as a yolk sac tumour during a histopathologic investigation of the material which was done, which was received by doing a tru-cut biopsy. The patient was discharged after 3 he took courses of BEP (Bleomycin, Etoposide, Cisplatin) treatment . A post-operative tumoural mass necrosis and the presence of a GT inside this mass were identified. In the histopathologic examination, glomus tumour was found to consist of uniform, round or oval cells with round or oval nuclei and pale eosinophilic cytoplasm. Tumour cells were arranged in sheets or nests patterns, and they were found to surround vessels. The tumour cells were stained by PAS and they were diffusely positive for SMA [Table/ Fig-1]. The MIB-1 index was about 1-2%. Glomus tumour was diagnosed on the basis of these features. Chemotherapy of the patient was continued. The patient is still being followed up by us without any problem.

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Chemodectoma of the head and neck: Results of treatment in 84 patients

Cited by 106 publications

References 27 publications

Gamma Knife Radiosurgery for Glomus Jugulare and Tympanicum

Gamma Knife Radiosurgery for Glomus Jugulare and Tympanicum

The management of head-and-neck paragangliomas

Coexistence of Glomangioma and Yolk Sac Tumour in a Child: A Case Report

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