Chemodivergent, multicomponent-tandem facile synthesis of novel 1H-pyrazolo[1,2-b]phthalazine-5,10-dione using acetic acid functionalized imidazolium salt {[cmdmim]I} as a recyclable catalyst

Abstract

A novel one-pot four-component, highly efficient and environmentally benign approach for the synthesis of a wide range of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives in the presence of acetic acid functionalized imidazolium salt as a newly synthesized Brønsted acid catalyst is described.

Synthesis, delivery, and molecular docking of fused quinolines as inhibitor of Hepatitis A virus 3C proteinase

“…Although above mentioned studies have proposed methods with the aim using into pharmaceutical industries, they have low relative yield and high reaction time. So, in current study, we propose a novel method to synthesis of fused quinolines with excellent yield and short reaction time using 1-carboxymethyl-2,3-dimethylimidazolium iodide ([cmdmim]I) ionic liquid catalyst 43 . In fact, the [cmdmim]I as one of recyclable catalysts mainly results in straightforward work-up procedure, and reusability of the catalyst in about 5 consecutive runs without any appreciable decrease in activity 43 .…”

“…So, in current study, we propose a novel method to synthesis of fused quinolines with excellent yield and short reaction time using 1-carboxymethyl-2,3-dimethylimidazolium iodide ([cmdmim]I) ionic liquid catalyst 43 . In fact, the [cmdmim]I as one of recyclable catalysts mainly results in straightforward work-up procedure, and reusability of the catalyst in about 5 consecutive runs without any appreciable decrease in activity 43 . In fact, ionic liquids have important role into synthesis of these compounds on pharmaceutical industries.…”

γ‐Fe2O3@HAp@PBABMD@Cu magnetic nanoparticles: Efficient, green, and recyclable novel nanocatalyst for the synthesis of densely functionalized pyrrole‐pyrido[2,3‐d]pyrimidine hybrids

“…Considering the biological importance of pyrrole scaffolds, development of one-pot synthetic routes to construct a heterocyclic system containing this structural motif remains a topic of attention. [36][37][38][39][40][41][42] One of the main principles of green chemistry is to avoid the use or production of dangerous substances in the design, making, and application of the chemical product. On the basis of this fact, designing new methods by employing multi-component reactions (MCR) without using any harmful organic solvents [43][44][45][46] and using heterogeneous, recyclable catalysts makes these reactions powerful green chemical technology procedures, resulting in minimal pollution and waste material.…”

“…Similarly, the pyrrole skeleton, which is one of the most prominent N ‐heterocycles, is the key structure in natural and pharmaceutically substantial molecules and exhibited an extensive range of biological activities (Figure 1d,e). Considering the biological importance of pyrrole scaffolds, development of one‐pot synthetic routes to construct a heterocyclic system containing this structural motif remains a topic of attention 36–42 . One of the main principles of green chemistry is to avoid the use or production of dangerous substances in the design, making, and application of the chemical product.…”

Ag/CuO/MCM-48 AS A POTENTIAL CATALYST FOR THE SYNTHESIS OF SYMMETRICAL AND UNSYMMETRICAL POLYHYDROQUINOLINES

“…As a continuation of our ongoing endeavors in developing novel and practical multicomponent reactions to synthesize heterocyclic compounds of biological importance [37][38][39][40][41][42][43][44][45], we herein present the catalytic efficiency of Ag/CuO/MCM-48 for the multicomponent synthesis of symmetrical and unsymmetrical polyhydroquinoline derivatives under identical reaction conditions (Scheme 1). Recently, unsymmetrical polyhydroquinoline motifs have been recognized as lead molecules in antidiabetic drug discovery [46].…”