Chemoembolization Combined With Radiofrequency Ablation for Patients With Hepatocellular Carcinoma Larger Than 3 cm

Cheng, Baoquan; Jia, Chong-Qi; Liu, Chun‐Tao; Fan, Wei; Wang, Qingliang; Zhang, Zongli; Yi, Cuihua

doi:10.1001/jama.299.14.1669

Cited by 181 publications

(88 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, sarcomatous appearance was most frequent in cases with repeated TAE (48). In addition, TACE combined with radiofrequency ablation (RFA) therapy was superior to TACE alone in improving survival for patients with HCC (49). RFA combined with TACE in patients with early-stage HCC provides overall and disease-free survival rates similar to those achieved by hepatectomy (50).…”

Section: Discussionmentioning

confidence: 99%

Hypoxia-induced des-γ-carboxy prothrombin production in hepatocellular carcinoma

Murata

Suzuki²,

Okano³

et al. 2009

Int J Oncol

View full text Add to dashboard Cite

Abstract. Des-Á-carboxy prothrombin (DCP) is an established HCC tumor marker, but the precise mechanism of its production is still unclear. Recently, we demonstrated that cytoskeletal changes during epithelial-to-fibroblastoid conversion (EFC) or epithelial mesenchymal transition (EMT) induced by chemicals plays a critical mechanistic role in DCP production via impairment in vitamin K uptake. Our proposed mechanism of DCP production is consistent with substantial clinical evidence. Supplementary vitamin K2 analogues reduced serum DCP levels in hepatocellular carcinoma (HCC) patients. HCC patients with high serum DCP are associated with vascular invasion, metastasis and tumor recurrence. On the other hand, hypoxia has been reported to induce EMT or cytoskeletal changes. Therefore, we examined whether hypoxia induced DCP production during EFC or EMT in HCC cells. Indeed, hypoxic stimulation induced hepatoma cell lines (HepG2 or PLC/PRF/5 cells) to undergo EFC or EMT and these cells produced DCP. Immunofluorescence study demonstrated that hypoxic stimulation impaired labeled low-density lipoprotein uptake, which was a surrogate for vitamin K uptake. In addition, fine filamentous actin network, which has crucial role for clathrin-mediated endocytosis of vitamin K, was disrupted in DCP producing cells by hypoxic stimulation. Thus, hypoxic stimulation induced HCC cells to produce DCP in the same mechanism as chemicals. Furthermore, immunohistochemical study using surgically resected HCC samples showed that a positive staining of nuclear hypoxia inducible factor (HIF)-1· was more frequently observed in HCC cells with stronger staining intensity of DCP. Importantly, clinical observations that DCP as an HCC tumor marker was more useful in larger tumors, which is likely to be exposed with hypoxia during tumor development, support our results.

show abstract

Section: Discussionmentioning

confidence: 99%

Hypoxia-induced des-γ-carboxy prothrombin production in hepatocellular carcinoma

Murata

Suzuki²,

Okano³

et al. 2009

Int J Oncol

View full text Add to dashboard Cite

show abstract

“…Various clinical studies, involving combination of transcatheter arterial chemoembolization followed by RFA [306] or hepatic arterial balloon occlusion during RFA [307], have been attempted to increase the ablated volume of RFA by reducing the cooling effect of the blood supply. Although the extension of necrotic area was achieved, it still remains unsettled whether these trials actually improve the prognosis or not.…”

Section: Local Ablation Is a First-line Treatment Of Unresectable Smmentioning

confidence: 99%

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

et al. 2010

View full text Add to dashboard Cite

Introduction The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party on the management of hepatocellular carcinoma (HCC) in December 2008 to develop consensus recommendations. Methods The working party consisted of expert hepatologist, hepatobiliary surgeon, radiologist, and oncologist from Asian-Pacific region, who were requested to make drafts prior to the consensus meeting held at Bali, Indonesia on 4 December 2008. The quality of existing evidence and strength of recommendations were ranked from 1 (highest) to 5 (lowest) and from A (strongest) to D (weakest), respectively, according to the Oxford system of evidence-based approach for developing the consensus statements. 123Hepatol Int (2010) 4: 439-474 DOI 10.1007/s12072-010-9165-7 Results Participants of the consensus meeting assessed the quality of cited studies and assigned grades to the recommendation statements. Finalized recommendations were presented at the fourth APASL single topic conference on viral-related HCC at Bali, Indonesia and approved by the participants of the conference.

show abstract

“…Clinical studies have been conducted to evaluate the TACE-RFA procedure in HCC patients. Cheng et al were among the first to report a clinical trial involving TACE-RFA in patients with HCC tumour sizes from 3 to 7.5 cm [102]. It has been shown that patients treated with TACE-RFA had better overall survival than those treated with TACE alone or RFA alone.…”

Section: Combination With Other Treatment Optionsmentioning

confidence: 99%

The Roles of Doxorubicin in Hepatocellular Carcinoma

Tam¹

2013

ADMET DMPK

View full text Add to dashboard Cite

show abstract

Chemoembolization Combined With Radiofrequency Ablation for Patients With Hepatocellular Carcinoma Larger Than 3 cm

Abstract: Editorials represent the opinions of the authors and JAMA and not those of the American Medical Association. Retraction: Cheng B-Q, et al. Chemoembolization combined with radiofrequency ablation for patients with hepatocellular carcinoma larger than 3 cm: a randomized controlled trial.

Cited by 181 publications

References 31 publications

Hypoxia-induced des-γ-carboxy prothrombin production in hepatocellular carcinoma

Hypoxia-induced des-γ-carboxy prothrombin production in hepatocellular carcinoma

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

The Roles of Doxorubicin in Hepatocellular Carcinoma

Contact Info

Product

Resources

About