Chemoembolization of Head and Neck Cancer with Carboplatine Microcapsules

Abstract

Fourteen patients with malignant tumor in the head and neck region were treated with infusion of carboplatine microcapsules (CBDCA-mc) via percutaneous super-selective catheterization. A microcatheter was advanced into a feeding artery using a coaxial catheter system. Eleven patients had over 30% reduction of the tumor size on CT within 1 month after embolization. Twelve patients had an increased amount of low attenuation tissue in the tumor on CT after embolization, suggesting increased necrosis in the tumor. No definite hematologic toxicity was found. A majority of patients complained of moderate pain in the embolized region immediately after embolization, easily relieved by i.v. analgesics. Chemoembolization using CBDCA-mc may be an effective therapeutic modality in advanced cases of head and neck cancer.

Transcatheter arterial chemoembolization is safe and effective for patients with late-stage or recurrent oral carcinoma

“…Mild complications were observed in this study, and local pain was the most common complication. This was similar to the study by Tomura et al (6), in which only mild-tomoderate local pain was observed after TACE using carboplatin microcapsules.…”

“…Regine et al (18) reported that transcatheter cisplatin infusion is feasible for late-stage cancer of the head and neck if combined with hyperfractionated radiation therapy. Currently, there are few studies reporting the clinical outcomes of TACE for treating latestage or recurrent oral carcinoma (6,9). Kovaces et al (9) reported that TACE using degradable starch microspheres and cisplatin showed a high overall response for late-stage cancer of the head and neck.…”

“…Kovaces et al (9) reported that TACE using degradable starch microspheres and cisplatin showed a high overall response for late-stage cancer of the head and neck. Tomura et al (6) performed TACE using carboplatin microcapsules for 14 patients with malignant tumors in the head and neck and achieved obvious tumor reduction.…”

“…Besides, preoperative TACE has also been used to decrease tumor size to improve surgical success rate or reduce the recurrence rate of postoperative tumors (7,8). To date, few studies that have reported the clinical outcomes of TACE for treating late-stage or recurrent oral carcinoma (6,9). In this study, we reported the long-term outcomes of TACE for treating patients with latestage or recurrent oral carcinoma.…”

“…Transcatheter chemoembolization (TACE) has been widely performed for the palliative treatment of late-stage carcinomas (2, 3), including advanced head and neck cancers (4)(5)(6). Besides, preoperative TACE has also been used to decrease tumor size to improve surgical success rate or reduce the recurrence rate of postoperative tumors (7,8).…”