Chemoenzymatic surface decoration of Nisin-shelled nanoemulsions: Novel targeted drug-nanocarriers for cancer applications

Hashad, Rania A.; Singla, Ritu; Bhangu, Sukhvir Kaur; Jap, Edwina; Zhu, Hehua; Peleg, Anton Y.; Blakeway, Luke V.; Hagemeyer, Christoph E.; Cavalieri, Francesca; Ashokkumar, Muthupandian; Alt, Karen

doi:10.1016/j.ultsonch.2022.106183

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Biomimetic stiffening of cell-laden hydrogels via sequential thiol-ene and hydrazone click reactions ( Chang et al, 2021 ). Furthermore, nanoscale covalent organic frameworks (COFs) ( Guan et al, 2022 ), Nisin-shelled nanoemulsion ( Hashad et al, 2022 ), and MSCs-mediated deep tumor delivery of gold nanorod ( Figure 1G ) ( Yun et al, 2022 ) had been synthesized for anti-tumor therapy via thiol-ene reactions, SPAAC, and SPAAC, respectively. Moreover, pH-sensitive polysaccharide-gold nanorod conjugate ( Hou et al, 2019 ) and polymer nanomicelle platform ( Figure 1H ) ( Liao et al, 2021 ) were reported to treat cancers via hydrazone click reaction and CuAAC, respectively.…”

Section: Click Chemistrymentioning

confidence: 99%

Recent updates in click and computational chemistry for drug discovery and development

et al. 2023

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Drug discovery is a costly and time-consuming process with a very high failure rate. Recently, click chemistry and computer-aided drug design (CADD) represent popular areas for new drug development. Herein, we summarized the recent updates in click and computational chemistry for drug discovery and development including clicking to effectively synthesize druggable candidates, synthesis and modification of natural products, targeted delivery systems, and computer-aided drug discovery for target identification, seeking out and optimizing lead compounds, ADMET prediction as well as compounds synthesis, hopefully, inspires new ideas for novel drug development in the future.

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Section: Click Chemistrymentioning

confidence: 99%

Recent updates in click and computational chemistry for drug discovery and development

et al. 2023

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“…Nisin has been widely used in various industries, such as the biomedical, pharmaceutical, agricultural, and food fields. It has been used in a variety of food products, including dairy products, meat products, beverages, and vegetables, which can effectively inhibit the contamination of food-borne pathogens and prolong the shelf life of foods [ 8 ]. However, the antimicrobial activity of nisin is reduced in practical applications because of its interaction with food matrices, low resistance to proteases, and poor stability at pH levels close to neutral and alkaline [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Nanoscale Modification of Nisin by Different Milk-Derived Proteins on Its Physicochemical Properties and Antibacterial Activity

Wang,

Liu,

Huang

et al. 2024

Foods

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Nisin is used as a natural food preservative because of its broad-spectrum antimicrobial activity against Gram-positive bacteria. However, free nisin is susceptible to various factors that reduce its antimicrobial activity. Milk protein, a protein derived from milk, has self-assembly properties and is a good carrier of bioactive substances. In this study, lactoferrin–nisin nanoparticles (L-N), bovine serum albumin–nisin nanoparticles (B-N), and casein–nisin nanoparticles (C-N) were successfully prepared by a self-assembly technique, and then their properties were investigated. The studies revealed that lactoferrin (LF) and nisin formed L-N mainly through hydrophobic interactions and hydrogen bonding, and L-N had the best performance. The small particle size (29.83 ± 2.42 nm), dense reticular structure, and good thermal stability, storage stability, and emulsification of L-N laid a certain foundation for its application in food. Further bacteriostatic studies showed that L-N enhanced the bacteriostatic activity of nisin, with prominent inhibitory properties against Listeria monocytogenes, Staphylococcus aureus, and Bacillus cereus, which mainly disrupted the cell membrane of the bacteria. The above results broaden our understanding of milk protein–nisin nanoparticles, while the excellent antibacterial activity of L-N makes it promising for application as a novel food preservative, which will help to improve the bioavailability of nisin in food systems.

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“…Flow-through ultrasonication method was used by Hashad et al [6] to produce spherical and uniformly dispersed nisin-shelled nanovesicles with long term stability, low toxicity and able to accommodate a high concentration of anticancer drugs and augment their cytotoxic effect. The nisin shelled nanovesicles were exploited for the site-specific attachment of a recombinantly produced cancer targeting ligand (αHER2LPETG IgG) and showed cancer-specific binding and augmented cytotoxicity to HER2 expressing tumour cells.…”

mentioning

confidence: 99%

Special issue on “Ultrasound-assisted engineering of materials for biomedical uses”

Besford

Cavalieri

2022

Ultrasonics Sonochemistry

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Chemoenzymatic surface decoration of Nisin-shelled nanoemulsions: Novel targeted drug-nanocarriers for cancer applications

Cited by 6 publications

References 23 publications

Recent updates in click and computational chemistry for drug discovery and development

Recent updates in click and computational chemistry for drug discovery and development

The Effect of Nanoscale Modification of Nisin by Different Milk-Derived Proteins on Its Physicochemical Properties and Antibacterial Activity

Special issue on “Ultrasound-assisted engineering of materials for biomedical uses”

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