Chemokine and Cytokine Profiles in Patients with Hand Osteoarthritis

Abstract

Background: The development of hand osteoarthritis (HOA) and its progression into the erosive subset are unclear, but inflammation is suspected to be the main source. To verify the involvement of inflammation in HOA pathogenesis, we evaluate serum inflammatory mediators and their association with HOA-related clinical features in patients. Methods: 153 participants (50 non-erosive HOA patients, 54 erosive HOA patients, and 49 healthy control subjects) were included in this study. All patients underwent clinical examination, which included assessment of tender and swollen small hand joints, ultrasound (US) examination, and self-reported measures (e.g., AUSCAN or algofunctional indexes). Serum inflammatory mediators were quantified using human cytokine 27-plex immunoassay. We employed linear modelling, correlation analysis, and resampling statistics to evaluate the association of these mediators to HOA. Results: We identified increased levels of nine inflammatory mediators (e.g., eotaxin, monocyte chemoattractant protein 1, interleukin-8, and tumour necrosis factor) in HOA patients compared to healthy controls. Increased mediators correlated with ultrasound findings as well as with clinically tender and swollen joint counts in patients with erosive HOA. However, none of the mediators distinguished between erosive and non-erosive HOA subtypes. Conclusion: Our findings support the hypothesis on the involvement of inflammation in HOA.

Genetically predicted circulating levels of cytokines and the risk of osteoarthritis: A mendelian randomization study

“…Previous studies have shown that OA patients have higher circulating levels of several inflammatory cytokines than healthy controls. For example, Jiří Baloun et al (2020) showed elevated levels of nine inflammatory mediators (e.g., eosinophil chemokine, monocyte chemotactic protein 1, interleukin-10(IL-10), and tumour necrosis factor) in patients with hip osteoarthritis ( Baloun et al, 2020 ). In a meta-analysis designed for 682 individuals, elevated monocyte chemotactic protein-1 (MCP-1) concentrations were observed in patients with OA but not in healthy controls ( Ni et al, 2020 ).…”