Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study

Waśkiel‐Burnat, Anna; Niemczyk, Anna; Blicharz, Leszek; Chmielińska, Paulina; Zaremba, Michał; Filipiak‬, Krzysztof J.; Olszewska, Małgorzata; Rudnicka, Lidia

doi:10.3390/jcm10225418

Cited by 7 publications

(6 citation statements)

References 22 publications

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“… 35 Elevated levels of CCL7 are present in laparoscopic aspiration samples from adults with endometriosis, 36 and uterine CCL7 production has been associated with leukocyte chemotaxis in cervical ripening, 37 and with preterm delivery. 38 Serum and plasma levels of CCL7 have been proposed as biomarkers of atherosclerosis, 39 systemic sclerosis, 40 and severity of COVID‐19 infection. 41 Elevated plasma levels of both TGF‐β and CCL7 have also been associated with amnestic mild cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

A cross‐sectional study comparing the inflammatory profile of menstrual effluent vs. peripheral blood

Naseri

Rosenberg-Hasson

Maecker

et al. 2023

Health Science Reports

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Background and Aims Cytokine profiles of peripheral blood and other bodily fluids provide diagnostic indicators for assessing inflammatory processes. Menstrual effluent may provide a noninvasive source of biological material for monitoring cytokine levels in blood and in endometrial tissues. This pilot study investigated the potential of measuring cytokines in menstrual effluent, and compared the cytokine profiles of menstrual versus peripheral blood. Methods Seven healthy donors (aged ≥18 and ≤45 years) collected menstrual effluent on day 2 of menses. Matched peripheral blood samples were collected by venous blood draw on the same day. Levels of 62 cytokines were measured in all samples by 62‐plex Luminex assay. Results Peripheral blood and menstrual effluent cytokine profiles were tenuously correlated ( r 2 = 0.26, p < 0.0001), with higher levels detected in menstrual effluent for 48/62 cytokines. Thirty five cytokines were significantly elevated in menstrual effluent compared to peripheral blood samples (IL‐8, CCL2, CCL4, LIF, IL‐1RA, IL‐6, IL‐1β, HGF, CCL3, FGF‐2, TNF‐α, VEGF‐A, IL‐1α, CXCL1, IL‐9, IL‐10, EGF, CXCL5, CSF3, EOTAXIN, TGF‐α, TRAIL, CXCL10, VEGF‐D, IL‐12P40, CXCL9, IL‐18 RESISTIN, IL‐22, IL‐21, CSF1, IFN‐γ, IL‐17A, CXCL12, IL‐12p70). Two cytokines (LEPTIN, CSF2) were expressed at significantly lower levels in menstrual effluent compared to peripheral blood. Linear regression of individual cytokines found low predictive power (linear regression p > 0.05) for 53/62 cytokines in menstrual effluent versus peripheral blood. Levels of TGF‐β ( r 2 = 0.87, p = 0.002) and CCL7 ( r 2 = 0.63, p = 0.033) were significantly positively correlated between matched menstrual and peripheral blood samples. Conclusion In this group of study participants, the cytokine profile of menstrual effluent was quantitatively distinct from peripheral blood, and also characterized by higher levels of inflammatory signaling. This pattern of comparative menstrual blood cytokine profiles points to a need for further studies to evaluate the relationship between peripheral and menstrual blood cytokines in broader populations including both healthy and diseased states.

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Section: Discussionmentioning

confidence: 99%

A cross‐sectional study comparing the inflammatory profile of menstrual effluent vs. peripheral blood

Naseri

Rosenberg-Hasson

Maecker

et al. 2023

Health Science Reports

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“…43 Another study investigating the connection between atherosclerosis and AA found that when evaluating the serum concentrations of proinflammatory proteins, particularly CCL7, there was a positive correlation between the serum concentration of CCL7 and the severity of AA (r = 0.281; p = 0.03), suggesting that the severity of AA may be associated with an increased risk of atherosclerosis. 55 Another study with 89 patients with AA found significantly higher plasma levels of cardiac troponin I (cTnI) and CRP in patients with AA compared to patients with AGA and controls without hair loss. 56 They also found that AA plasma samples with high cardiac troponin levels induced significantly higher rates of cardiomyocyte apoptosis in cell culture assays.…”

Section: Aamentioning

confidence: 99%

“…Furthermore, patients with AA totalis/universalis showed the greatest systemic inflammatory tone relative to all the other patient cohorts, as shown by the greater degree of dysregulation of CV/atherosclerosis/immune/Th1/Th2 pathways and biomarkers 43 . Another study investigating the connection between atherosclerosis and AA found that when evaluating the serum concentrations of proinflammatory proteins, particularly CCL7, there was a positive correlation between the serum concentration of CCL7 and the severity of AA ( r = 0.281; p = 0.03), suggesting that the severity of AA may be associated with an increased risk of atherosclerosis 55 …”

Section: Nonscarring Alopeciasmentioning

confidence: 99%

Cardiovascular risk in patients with scarring and nonscarring alopecias: Assessing the current state of evidence

Sally,

Robinson,

Orlow

et al. 2023

JEADV Clinical Practice

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Alopecia is traditionally classified into scarring and nonscarring subtypes, with etiopathologies ranging from androgen‐mediated to immuno‐inflammatory. Over 50% of men and almost 50% of women will experience some form of hair loss in their lifetime. Given this prevalence and the psychosocial significance of hair, understanding the pathophysiology and comorbidities of different types of hair loss is imperative. Other proinflammatory dermatologic disorders, such as psoriasis, are recognised to have systemic manifestations including an increased risk of cardiovascular (CV) disease, and are now considered CV risk‐enhancing conditions. With increased recognition of the importance of systemic inflammation in promoting atherosclerosis, high prevalence, and improved treatment strategies, there is increased interest in establishing whether a similar association between alopecia and cardiovascular disease (CVD) exists. In this manuscript, we aim to review the current literature regarding CV risk in androgenic alopecia (AGA) and alopecia areata (AA). Additionally, we review the literature for cicatricial alopecias and highlight the need for more research into their potential associations with CV risk. Evidence from the identified AGA publications suggests an association of AGA with CV risk factors including hypertension, dyslipidemia, and insulin resistance, as well as with coronary artery disease. For AA, most of the identified studies found an association between AA and CV risk, though the relationships were not always statistically significant. Research on cicatricial alopecias and CV risk is limited and often contradictory. There is great need for more studies regarding the association between various types of alopecia and the development of CVD, and potential mechanisms. Particularly needed are more studies of cicatricial alopecias and potential associated CV risk. While some literature suggests that patients with alopecia have an increased risk of CVD, the lack of concrete evidence represents a notable gap in our current understanding.

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“…The cardiovascular risk was calculated with various validated cardiovascular risk scoring systems: QRESEARCH risk estimator version 3 (QRISK-3) [6] in all patients; Framingham Risk score -Coronary heart disease (FRS-CHD) [7] and Framingham Risk Score -Cardiovascular Disease (FRS-CVD) [8] in patients at the age of 30 or above; Atherosclerotic Cardiovascular Disease (ASCVD) Risk Estimator Plus [9] and Systematic Coronary Risk Evaluation (SCORE) Dane dotyczące ryzyka sercowo-naczyniowego u osób z łysieniem plackowatym są jednak ograniczone [3].…”

Section: Cardiovascular Risk Assessmentmentioning

confidence: 99%

“…To date, there have been limited data considering the cardiovascular risk in patients with alopecia areata [3]. streszczenie Wprowadzenie: Z licznych badań wynika, że łysienie plackowate wiąże się z układowym stanem zapalnym z podwyższonym stężeniem cytokin prozapalnych w surowicy.…”

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Cardiovascular risk in patients with alopecia areata: a cross-sectional study

Waśkiel‐Burnat¹,

Dorobek²,

Kotowska³

et al. 2023

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Introduction:Numerous studies indicate that alopecia areata is associated with systemic inflammation with an increased serum level of proinflammatory cytokines. Recent studies have indicated a higher incidence of cardiovascular diseases in patients with alopecia areata. Objective: To evaluate the cardiovascular risk calculated with various scoring systems in patients with alopecia areata compared to the controls. Material and methods:In the present study, the cardiovascular risk was evaluated in 91 patients with alopecia areata and 47 controls with the use of QRESEARCH risk estimator version 3 (QRISK-3), Framingham Risk score -Coronary heart disease (FRS-CHD), Framingham Risk Score -Cardiovascular disease (FRS-CVD), Atherosclerotic Cardiovascular Disease (ASCVD) Risk Estimator Plus and Systematic Coronary Risk Evaluation (SCORE) risk charts.Results: An increased median QRISK-3 was observed in patients with alopecia areata compared to controls (1.2 [0.5-5.5] vs. 0.9 [0.2-3.2]; p < 0.05). Moreover, higher median FRS-CHD, FRS-CVD, ASCVD Risk Estimator Plus scores were detected in patients with alopecia areata compared to control subjects (4.5 (2.4-9) vs. 3.35 (1.5-6.7); 0.85 (0.1-2.4) vs. 0.45 (0.1-1) and 2.5 (0.7-8.2) vs. 1.9 (0.8-4.3), respectively). However, those differences were not statistically significant (p > 0.05). In patients with alopecia areata, a positive correlation was observed between QRISK-3 and the age of the patient, body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, LDL-cholesterol and triglycerides. Conclusions: Alopecia areata is associated with an increased cardiovascular risk. Regular cardiovascular screening should be recommended to every patient with alopecia areata.

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Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study

Cited by 7 publications

References 22 publications

A cross‐sectional study comparing the inflammatory profile of menstrual effluent vs. peripheral blood

A cross‐sectional study comparing the inflammatory profile of menstrual effluent vs. peripheral blood

Cardiovascular risk in patients with scarring and nonscarring alopecias: Assessing the current state of evidence

Cardiovascular risk in patients with alopecia areata: a cross-sectional study

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