Chemokine (C-X-C) ligand 1 (CXCL1) protein expression is increased in aggressive bladder cancers

Miyake, Makito; Lawton, Adrienne; Goodison, Steve; Urquidi, Virginia; Gomes-Giacoia, Evan; Zhang, Ge; Ross, Shanti; Kim, Jeong-Soon; Rosser, Charles J.

doi:10.1186/1471-2407-13-322

Cited by 61 publications

(62 citation statements)

References 30 publications

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“…The IHC staining pattern revealed that GROα protein was localized in the cytoplasm of cancer cells. It has been previously reported that positive GROα staining is diffuse and not associated with any specific cell types [28]. The reason for the different localization of GROα might be because of the use of dissimilar antibodies as well as differences in the samples collected.…”

Section: Discussionmentioning

confidence: 99%

GROα expression and its prognostic implications in laryngeal squamous cell carcinoma

Liang¹,

Liu²,

Chen³

et al. 2015

neo

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The growth-regulated oncogene α (GROα) , which is also designated as CXC chemokine ligand 1 (CXCL1), was first identified as an autocrine growth factor in human malignant melanoma. It is involved in tumor development and invasion, and is highly expressed in various human cancers. However, little is known about the association between GROα expression and the clinical attributes of laryngeal squamous cell carcinoma (LSCC).One-step quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and immunohistochemical staining of tissue microarrays were employed to evaluate the relationship between GROα expression and LSCC clinicopathological attributes.GROα mRNA and protein expression levels were significantly greater in LSCC than in non-cancerous tumor-adjacent tissues. GROα protein expression in LSCC was also significantly associated with TNM stage, lymph node metastasis, and histopathological grade. Kaplan-Meier and Cox multi-factor analyses suggested that increased GROα expression and positive lymph node metastasis were significantly associated with the poor survival of LSCC patients.These data indicate that GROα may be a novel prognostic marker of LSCC.

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Section: Discussionmentioning

confidence: 99%

GROα expression and its prognostic implications in laryngeal squamous cell carcinoma

Liang¹,

Liu²,

Chen³

et al. 2015

neo

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“…Furthermore, the HPV-positive patients had shorter OS and PFS compared with the HPV-negative patients, but only the levels of HGF, FIGO stage and pelvic lymph node metastasis were independent prognostic factors in the multivariate Cox analysis. Cheng et al (42) reported that GRO-1 may be a promising adverse prognostic molecular marker, and Miyake et al (43) confirmed the poor prognostic value of GRO-1 in bladder cancer. Numerous studies have demonstrated the prognostic value of sE-selectin in colorectal cancer (31,34).…”

Section: ------------------------------------------------------------mentioning

confidence: 97%

Expression of growth-regulated oncogene-1, hepatocyte growth factor, platelet-derived growth factor-AA and soluble E-selectin and their association with high-risk human papillomavirus infection in squamous cell carcinoma of the uterine cervix

Zhang

Yang

et al. 2014

Molecular Medicine Reports

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Abstract. The aim of the present study was to evaluate the clinical significance and prognostic value of growth-regulated oncogene-1 (GRO-1), hepatocyte growth factor (HGF), platelet-derived growth factor-AA (PDGF-AA), soluble E-selectin (sE-selectin) and high-risk human papillomavirus (HPV; types 16, 18/45, 31 and 33/52/58/67) infection in cervical squamous cell carcinoma (CSCC). A total of 426 cases were enrolled in the present study, of which 292 cases were patients with CSCC, 43 were patients with cervical intraepithelial neoplasia (CIN) and 91 were healthy controls. Luminex xMAP technology was used to detect the serum levels of GRO-1, HGF, PDGF-AA and sE-selectin in all cases and two-channel fluorescence quantitative polymerase chain reaction was used to determine HPV DNA in cervical scrapings from CSCC and CIN patients. The results demonstrated that the serum levels of GRO-1, HGF and sE-selectin were significantly higher in patients with CSCC compared with patients with CIN and the healthy controls (P<0.0001). Compared with the CIN patients, the HPV positive rate in the CSCC patients significantly increased (P= 0.013). The four factors were correlated with certain clinicopathological variables of CSCC patients to a certain degree (P<0.05) and the levels of HGF were closely associated with HPV infection (P= 0.039). The receiver operating characteristic curves demonstrated that HGF obtained the highest diagnostic value compared with the other three factors. Multivariate Cox regression analysis demonstrated that the serum levels of HGF (P<0.0001), FIGO stage (P<0.0001) and pelvic lymph node metastasis (P=0.001) were independent prognostic factors in patients with CSCC, while high-risk HPV infection did not show any significance in this analysis. These results demonstrated that HGF may be a useful prognostic biomarker rather than high-risk HPV types in patients with CSCC.

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“…[14][15][16][17] Chemokines are critical to the inflammatory response of humans and are secreted to recruit cells from the immune system in response to viral infection and allergic disorders. 18 Some chemokines are even suggested to be involved in modulating the migration of normal cells. Scientists have recently discovered that the deactivation of chemokines may implicate the initiation or progression of a variety of tumors.…”

Section: Introductionmentioning

confidence: 99%

MiR-1-3p inhibits the proliferation and invasion of bladder cancer cells by suppressing CCL2 expression

et al. 2017

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We attempted to analyze the effects of miR-1-3p and CCL2 on the proliferation, migration, and invasion of bladder cancer cells. A total of 18 pairs of bladder cancer tissues with corresponding adjacent tissues and the 6 cases of normal tissues were collected. The expressions of miR-1-3p and CCL2 in the cancer tissues were evaluated using quantitative real-time polymerase chain reaction and western blot. The relationship between miR-1-3p and CCL2 was assessed using luciferase reporter assay. The UM-UC-3 bladder cancer cells were transfected with CCL2 small interfering RNA and miR-1-3p mimics. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, colony formation assay, wound healing assay, Transwell assay, and the flow cytometry test were used to detect the proliferation, migration, invasion, and apoptosis of bladder cancer cells. Bladder cancer tissues had lower levels of miR-1-3p but higher levels of CCL2 than normal tissues (p < 0.05). The transfection of miR-1-3p mimics and CCL2 small interfering RNA remarkably suppressed cell proliferation and invasion and promoted apoptosis of cells (p < 0.05). Results of the luciferase reporter gene assay demonstrated that miR-1-3p targeted CCL2. MiR-1-3p suppresses the proliferation and invasion of urinary bladder cancer cells by targeting CCL2.

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Chemokine (C-X-C) ligand 1 (CXCL1) protein expression is increased in aggressive bladder cancers

Cited by 61 publications

References 30 publications

GROα expression and its prognostic implications in laryngeal squamous cell carcinoma

GROα expression and its prognostic implications in laryngeal squamous cell carcinoma

Expression of growth-regulated oncogene-1, hepatocyte growth factor, platelet-derived growth factor-AA and soluble E-selectin and their association with high-risk human papillomavirus infection in squamous cell carcinoma of the uterine cervix

MiR-1-3p inhibits the proliferation and invasion of bladder cancer cells by suppressing CCL2 expression

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