Chemokine (CCR) and fractalkine (CX3CR) receptors and end stage renal disease

Borkar, Minal; Tripathi, Gaurav; Sharma, Raj Kumar; Sankhwar, Satya Narayan; Agrawal, Suraksha

doi:10.1007/s00011-010-0284-3

Cited by 18 publications

(22 citation statements)

References 27 publications

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“…Cytokine genotypes have been studied in patients undergoing solid organ transplantation and certain polymorphisms have been implicated in the development of graft failure/survival . Presently, there are no laboratory assays proficient in predicting the incidence of acute/chronic rejection.…”

Section: Discussionmentioning

confidence: 99%

Prediction of susceptible biomarkers for end stage renal disease among North Indians

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Prediction of susceptible biomarkers for end stage renal disease among North Indians

et al. 2016

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“…Numerous studies have demonstrated that genetic factors are involved in the onset of ESRD (Borkar et al, 2011;George and Mittal, 2011;Prakash et al, 2012). As a disorder that impairs all metabolic processes associated with vitamin D, ESRD is unsurprisingly associated with vitamin D deficiency (Dusilová Sulková, 2012), which can lead to a series of complications in patients with renal disease.…”

Section: Introductionmentioning

confidence: 99%

Association of vitamin D receptor gene polymorphisms with end-stage renal disease and the development of high-turnover renal osteodystrophy in a Chinese population

Zhang

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Two single nucleotide polymorphisms (SNPs; TaqI and ApaI) in the vitamin D receptor (VDR) gene have been identified as risk factors for the progression of end-stage renal disease (ESRD). The purpose of our study was to confirm the reported association of these two SNPs with ESRD risk and progression of renal osteodystrophy in a Chinese Han population. A total of 452 ESRD patients and 904 matched-pair controls (based on age, gender, and body mass index) were included. Identification of VDR gene polymorphisms was performed using the polymerase chain reaction-restriction fragment length polymorphism method with TaqI and ApaI restriction enzymes. There was no association of the TaqI polymorphism with ESRD risk. However, significant associations were seen between ApaI (rs7975232) polymorphism and ESRD risk in the heterozygote model (AC/ AA; P = 0.002; OR = 1.4, 95%CI = 1.14-1.83), homozygote model (CC/AA; P = 0.007; OR = 1.8, 95%CI = 1.17-2.85) genotypes for rs7975232, allelic model (P < 0.001; OR = 1.4, 95%CI = 1.15-1.64), dominant model (P = 0.001; OR = 1.5, 95%CI = 1.19-1.87), and recessive model (P = 0.046; OR = 0.6, 95%CI = 0.42-1.00) between cases and healthy controls Moreover, we found a significant correlation between the genotype and allele distribution of ApaI and intact parathyroid hormone (iPTH) levels, where allele C carriers have increased iPTH levels. The ApaI polymorphism in the VDR gene appears to be a susceptibility locus for ESRD in Chinese individuals, and allele C carriers may have an increased risk of high-turnover renal osteodystrophy.

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“…4 Patients with ESRD display enhanced genomic damage, and DNA repair gene polymorphisms may affect DNA repair capacity and modulate susceptibility to ESRD. 5 Some investigations [6][7][8] suggested that genetic factors might play a key role in the onset of ESRD.…”

Section: Introductionmentioning

confidence: 99%

Association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease susceptibility

Zhou

Yin

Qin

2012

J Renin Angiotensin Aldosterone Syst

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Background and objective:The association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and end-stage renal disease (ESRD) risk is still controversial. A meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and ESRD susceptibility. Method: A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases. Conclusions:The results of our study support the idea that D allele or DD genotype was associated with increased risk of ESRD susceptibility in the overall populations, and DD genotype was associated with ESRD susceptibility in Caucasians.

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Chemokine (CCR) and fractalkine (CX3CR) receptors and end stage renal disease

Abstract: These results highlight the role of CCR5 and CX3CR1 in ESRD.

Cited by 18 publications

References 27 publications

Prediction of susceptible biomarkers for end stage renal disease among North Indians

Prediction of susceptible biomarkers for end stage renal disease among North Indians

Association of vitamin D receptor gene polymorphisms with end-stage renal disease and the development of high-turnover renal osteodystrophy in a Chinese population

Association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease susceptibility

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