Chemokine CXCL12 in neurodegenerative diseases: an SOS signal for stem cell-based repair

Li, Meizhang; Hale, James S.; Rich, Jeremy; Ransohoff, Richard M.; Lathia, Justin D.

doi:10.1016/j.tins.2012.06.003

Cited by 84 publications

(68 citation statements)

References 106 publications

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“…Our approach to examining the effects of AMD3100 in a complex in vitro microenvironmental model of neovascularization may prove significant for understanding the mechanisms of action of this and other drugs and associated molecules in promoting or inhibiting revascularization and for more clearly defining the experimental approach to testing or assessing the effects of such drugs in vitro and subsequently in vivo. Understanding such mechanisms as those exemplified here with CXCL12 in new blood vessel formation has translational implications that include inhibition of tumor progression and promotion of tissue repair and regeneration as diverse as peripheral arterial disease and ischemic injury, burn injury, neurodegenerative disease, and hematological regeneration [5][6][7]11,18,22,[56][57][58][59][60].…”

Section: Fig 6 Cd31 Blocks Integration Of Exogenous Huvecs Into Immmentioning

confidence: 99%

“…These include hematopoietic stem/ progenitor cell (HSC/HPC) trafficking, immune surveillance, blood vessel, cardiac and central nervous system formation during development, revascularization at sites of tissue injury, and the initiation and metastatic spread of tumors [1][2][3][4][5][6][7][8][9]. CXCL12 plasma levels are rapidly elevated in response to tissue damage, with increased CXCL12 concentrations correlating with the severity of injury, increased vascular endothelial growth factor (VEGF) plasma levels, and the associated rapid mobilization of proangiogenic cells into the circulation [10,11].…”

Section: Introductionmentioning

confidence: 99%

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The Hematopoietic Chemokine CXCL12 Promotes Integration of Human Endothelial Colony Forming Cell–Derived Cells into Immature Vessel Networks

Newey

Tsaknakis

Khoo

et al. 2014

Stem Cells and Development

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Section: Fig 6 Cd31 Blocks Integration Of Exogenous Huvecs Into Immmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Hematopoietic Chemokine CXCL12 Promotes Integration of Human Endothelial Colony Forming Cell–Derived Cells into Immature Vessel Networks

Newey

Tsaknakis

Khoo

et al. 2014

Stem Cells and Development

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“…13 CXCR4 is the receptor for SDF-1, and the SDF-1-CXCR4 axis plays important roles in inflammation, tissue repair, and organogenesis. 14 Several studies have demonstrated that mesenchymal stem cells can secrete SDF-1a and promote the survival and regeneration of progenitor cells and cardiac myocytes. [15][16][17] However, it remains unclear whether, after iPSC transplantation, SDF-1a is involved in and regulates the recovery process after retinal oxidative damage.…”

Section: Introductionmentioning

confidence: 99%

Induced Pluripotent Stem Cells Without c-Myc Ameliorate Retinal Oxidative Damage via Paracrine Effects and Reduced Oxidative Stress in Rats

Fang

Yang

Chiou³

et al. 2014

Journal of Ocular Pharmacology and Therapeutics

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Purpose: To investigate the efficacy and mechanisms of non-c-Myc induced pluripotent stem cell (iPSC) transplantation in a rat model of retinal oxidative damage. Methods: Paraquat was intravitreously injected into Sprague-Dawley rats. After non-c-Myc iPSC transplantation, retinal function was evaluated by electroretinograms (ERGs). The generation of reactive oxygen species (ROS) was determined by lucigenin-and luminol-enhanced chemiluminescence. The expression of brainderived neurotrophic factor, ciliary neurotrophic factor, basic fibroblast growth factor (bFGF), stromal cellderived factor (SDF)-1a, and CXCR4 was measured by immunohistochemistry and ELISA. An in vitro study using SH-SY5Y cells was performed to verify the protective effects of SDF-1a.Results: Transplantation of non-c-Myc iPSCs effectively promoted the recovery of the b-wave ratio in ERGs and significantly ameliorated retinal damage. Non-c-Myc iPSC transplantation decreased ROS production and increased the activities of superoxide dismutase and catalase, thereby reducing retinal oxidative damage and apoptotic cells. Moreover, non-c-Myc iPSC transplantation resulted in significant upregulation of SDF-1a, followed by bFGF, accompanied by a significant improvement in the ERG. In vitro studies confirmed that treatment with SDF-1a significantly reduced apoptosis in a dose-dependent manner in SH-SY5Y cells. Most transplanted cells remained in the subretinal space, with spare cells expressing neurofilament M markers at day 28. Six months after transplantation, no tumor formation was seen in animals with non-c-Myc iPSC grafts. Conclusions: We demonstrated the potential benefits of non-c-Myc iPSC transplantation for treating oxidativedamage-induced retinal diseases. SDF-1a and bFGF play important roles in facilitating the amelioration of retinal oxidative damage after non-c-Myc iPSC transplantation.

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“…Saznanja o tim genetskim mehanizmima koji definiraju adultnu neurogenezu te o tome na koji način neurodegenerativne bolesti utječu na stvaranje novih neurona, moglo bi biti od velikog značaja u ranom otkrivanju i lječidbenom pristupu ovim bolestima. Osim na neurodegenerativne bolesti moglo bi se utjecati i na kontrolu poremećaja raspoloženja, imajući na umu činjenicu da je hipokampalna tvorba važna ne samo za kognitivno održavanje već i za normalno emocionalno funkcioniranje 83,84 . Cilj istraživanja koja se provode je pronaći način da se potakne neuronalna plastičnost i omogući preživljenje novonastalih neurona u ranim stadijima psihoneuroloških bolesti te tako kontrolira simptomatologija koja pogađa kogniciju i emocije.…”

Section: Psihoneurološki Poremećaji I Adultna Neurogenezaunclassified

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2017

Med. flum.

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Sažetak. Donedavno se smatralo da se živčane stanice prestaju dijeliti u ranoj postnatalnoj ži-votnoj dobi, no posljednjih 20 godina mnoga istraživanja na tom polju dokazala su suprotno. Neurogeneza u odraslom mozgu dokazana je u većine sisavaca, uključujući i čovjeka. Proces se u fiziološkim uvjetima spontano odvija pretežno u dvjema germinativnim regijama u mozgu u kojima se nalaze neuralne matične stanice; u subgranularnoj zoni dentatne vijuge hipokampusa te subventrikularnoj zoni lateralnog ventrikula. Neuralne matične stanice u njima imaju veću sposobnost proliferacije i diferencijacije prema novim budućim neuronima, astrocitima i oligodendrocitima u odnosu na neuralne matične stanice drugih područja živčanog sustava. Sposobnost proliferacije i regeneracije koju ove dvije "niše" posjeduju ima važnu ulogu u prilagodbi mozga na vanjske podražaje tijekom odrastanja i sazrijevanja, što se naziva plastičnošću mozga. Germinativne "niše" u mozgu su specifičan mikrookoliš u kojem se uskom interakcijom specifič-nih proneurogenetskih čimbenika i rezidentnih neuralnih matičnih stanica te krvožilja stvaraju strogo kontrolirani uvjeti koji omogućuju proliferaciju, diferencijaciju, migraciju i sazrijevanje neuroblasta ili glioblastate preživljenje i integraciju novonastalih neurona i glijalnih stanica u postojeće sinaptičke mreže u mozgu. U slučaju narušavanja homeostaze tih i drugih germinativna središta u mozgu, dolazi do pojave raznih psihoneuroloških poremećaja. Boljim razumijevanjem funkcioniranja germinativnih mikrookoliša u mozgu otvaraju se nove mogućnosti u neuroznanosti u pravcu manipuliranja adultnom neurogenezom potičući stvaranje neurona de novo te na taj način liječenja spomenutih psihoneuroloških poremećaja.Ključne riječi: adultna neurogeneza; neuralne matične stanice; subgranularna zona; subventrikularna zona Abstract. Tillrecently was assumed that neural cells stop dividing in early postnatal period of life, but last two decades large ammount ofresearches on that field proved contrary. There are evidences confirming existance of adult neurogenesis in most mammalian species, including humans.This process occurs spontaneouslyin physiological termsin two germinal brain regionscontaining neural stem cells; in subgranular zone of hippocampal dentate gyrus and subventricular zone of lateral ventricule.Neural stem cells in this germinal regions posses higher proliferative and differential capacity toward new future neurons, astrocytes and oligidendrocytes than neural stem cells from other regions in nervous system. Proliferative and regenerative power of this two niches has important role in brain adjustment to exterior stimuli during life which is called neuroplasticity. Germinal niches in brain are specific microenvironment in which close interaction of specific proneurogenic factors and resident neural stem cells and blood vessels form strictly controled conditions providing neuroblast and glioblast proliferation, differentiation, migration andmaturation and also survival and integration of newly created neu...

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Chemokine CXCL12 in neurodegenerative diseases: an SOS signal for stem cell-based repair

Cited by 84 publications

References 106 publications

The Hematopoietic Chemokine CXCL12 Promotes Integration of Human Endothelial Colony Forming Cell–Derived Cells into Immature Vessel Networks

The Hematopoietic Chemokine CXCL12 Promotes Integration of Human Endothelial Colony Forming Cell–Derived Cells into Immature Vessel Networks

Induced Pluripotent Stem Cells Without c-Myc Ameliorate Retinal Oxidative Damage via Paracrine Effects and Reduced Oxidative Stress in Rats

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