Chemokine-directed migration of tumor-inhibitory neural progenitor cells towards an intracranially growing glioma

Neural Transmembrane Protease and Endothelial Gs Protein Activation in Cell Contact-dependent Signaling between Neural Stem/Progenitor Cells and Brain Endothelial Cells

“…genitor cells (28), human hematopoietic stem cells (29), and mesenchymal stem cells (30). In the NS/P cell vascular niches, endothelial CXCL10 might act on NS/P cells as a mobilization factor.…”

Neural Stem/Progenitor Cell Clones as Models for Neural Development and Transplantation

“…This study showed that C17.2 cells that were transduced to express luciferase (C17.2-luc) accumulated onto tumors in mice carrying Lewis lung carcinomas. In vitro analysis showed that accumulation of C17.2-luc cells on tumor-derived endothelium (TEC) can be inhibited by functional blocking antibodies against SDF-1alpha and CD49d suggesting the involvement of SDF-1alpha/CXCR4 receptor and alpha4-integrin in the recruitment of C17.2-luc cells (Allport et al, 2004 (Honeth et al, 2006). Upon transplantation, these modified cells showed enhanced migration towards glioma that expressed CXCR3 ligands, IP-10 and I-TAC, in comparison with parental HiB5 cells.…”

Novel Treatment Strategies for Malignant Gliomas Using Neural Stem Cells

“…It will also be important to elucidate the mechanisms involved in regulating the cellular mechanisms of NSC and BTSC migration, as this understanding may be used to identify drugs capable of inhibiting the migratory capacity of BTSCs, thus decreasing their malignant invasiveness. For example, cell surface chemokine receptors, such as CXCR3 46 and CXCR4, 47 are potent mediators involved in attracting NSCs to gliomas. NSCs express high concentrations of CXCR4 and blocking these surface receptors block NSC migration towards gliomas.…”