Chemokine <i>RANTES</i> Promoter Dimorphisms and Hepatocellular Carcinoma Occurrence in Patients with Alcoholic or <b>Hepatitis C</b> Virus–Related Cirrhosis

Charni, Faten; Sutton, Angéla; Rufat, Pierre; Laguillier, Christelle; Mansouri, Abdellah; Moreau, Richard; Ganne-Carrié, Nathalie; Trinchet, Jean–Claude; Beaugrand, Michel; Charnaux, Nathalie; Nahon, Pierre

doi:10.1158/1055-9965.epi-11-0341

Cited by 21 publications

(13 citation statements)

References 34 publications

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“…Although the connection between RANTES polymorphism and chemokine serum concentration and some malignancies has been demonstrated previously, we failed to confirm that phenomenon in BCC [35, 36]. Little is known about the role of RANTES in BCC.…”

Section: Discussioncontrasting

confidence: 54%

–2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma

Sobjanek¹,

Zabłotna²,

Szczerkowska-Dobosz³

et al. 2016

pdia

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IntroductionPolymorphic variants of MCP-1 and RANTES genes and their protein serum levels have been implicated in the increased risk and severity of several malignancies. However, the subject has not been explored in basal cell carcinoma (BCC) patients so far.AimTo investigate the association between monocyte chemoattractant protein 1 (MCP-1) (–2518 A/G) and RANTES (–403 G/A) polymorphism and risk and clinical course of BCC.Material and methodsThe study group consisted of 150 unrelated patients with BCC and 140 healthy, unrelated, age- and sex-matched volunteers. The polymorphisms were analysed using the amplification refractory mutation system polymerase chain reaction method (ARMS-PCR) and single specific primer-polymerase chain reaction (SSP-PCR). Serum cytokine levels were measured with ELISA.ResultsThe presence of the MCP-1 –2518 GG genotype was statistically more frequent in BCC patients and it increased the risk of BCC (OR = 2.63, p = 0.003). Genotype –330 GG was statistically more common in patients with less advanced tumours (OR = 2.8, p = 0.017). Monocyte chemoattractant protein 1 serum level was statistically higher with GG genotype. In the BCC group MCP-1 serum levels were decreased. Neither polymorphic variants of RANTES nor the chemokine serum concentration differed significantly between the study groups.ConclusionsThese findings suggest that –2518 A/G MCP-1 polymorphism may be involved in BCC pathogenesis.

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Section: Discussioncontrasting

confidence: 54%

–2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma

Sobjanek¹,

Zabłotna²,

Szczerkowska-Dobosz³

et al. 2016

pdia

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“…These genetic traits are capable of modulating several biological pathways involved in hepatocarcinogenesis, such as inflammation [63,64], oxidative stress [65,66], and iron [67,68] or lipid metabolism [69]. In this setting, other genetic modifiers of lipid turnover seem to impact HCC risk in association with PNPLA3 genotype.…”

Section: Pnpla3 In the Complex Genetic Heterogeneity Influencing Livementioning

confidence: 99%

PNPLA3 gene in liver diseases

Trépo

Romeo

Zucman‐Rossi

et al. 2016

Journal of Hepatology

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“…Alcohol is one of the major risks of liver injury and has been considered as a promoter for HCC (26). It has been found that patients with alcoholic cirrhosis and bearing two copies of the RANTES G-403 variant (2G-403 genotype) had a higher rate of HCC occurrence compared with patients carrying at least one RANTES A-403 allele (27). AFP has been reported to be higher in patients with HCC arising from chronic viral conditions compared to those with alcoholic liver disease (28).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Metabolite Biomarkers for Hepatocellular Carcinoma through Stratified Analysis by Gender, Race, and Alcoholic Cirrhosis

Xiao

Zhao

Varghese

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background The effects of hepatocellular carcinoma (HCC) on liver metabolism and circulating metabolites have been subjected to continuing investigation. This study compares the levels of selected metabolites in sera of HCC cases versus patients with liver cirrhosis and evaluates the influence of gender, race, and alcoholic cirrhosis on the performance of the metabolites as candidate biomarkers for HCC. Methods Targeted quantitation of 15 metabolites is performed by selected research monitoring (SRM) in sera from 89 Egyptian subjects (40 HCC cases and 49 cirrhotic controls) and 110 US subjects (56 HCC cases and 54 cirrhotic controls). Logistic regression models are used to evaluate the ability of these metabolites in distinguishing HCC cases from cirrhotic controls. The influences of gender, race, and alcoholic cirrhosis on the performance of the metabolites are analyzed by stratified logistic regression. Results Two metabolites are selected based on their significance to both cohorts. While both metabolites discriminate HCC cases from cirrhotic controls in males and Caucasians, they are insignificant in females and African Americans. One metabolite is significant in patients with alcoholic cirrhosis and the other in non-alcoholic cirrhosis. Conclusions The study demonstrates the potential of two metabolites as candidate biomarkers for HCC by combining them with α-fetoprotein and gender. Stratified statistical analyses reveal that gender, race, and alcoholic cirrhosis affect the relative levels of small molecules in serum. Impact The findings of this study contribute to a better understanding of the influence of gender, race, and alcoholic cirrhosis in investigating small molecules as biomarkers for HCC.

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Chemokine RANTES Promoter Dimorphisms and Hepatocellular Carcinoma Occurrence in Patients with Alcoholic or Hepatitis C Virus–Related Cirrhosis

Cited by 21 publications

References 34 publications

–2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma

–2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma

PNPLA3 gene in liver diseases

Evaluation of Metabolite Biomarkers for Hepatocellular Carcinoma through Stratified Analysis by Gender, Race, and Alcoholic Cirrhosis

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