Chemokine-like factor-like MARVEL transmembrane domain-containing family in autoimmune diseases

Duan, Hong-Ji; Liu, Chang; Duan, Xiaoli

doi:10.1097/cm9.0000000000000747

Cited by 29 publications

(27 citation statements)

References 82 publications

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“…CMKLR1 reportedly relieved allergic airway in ammation of asthma patients 28 . CMTM2, which belongs to the CMTM family, is highly expressed in peripheral blood mononuclear cells and is associated with numerous autoimmune diseases 29 . Neureg-ulin-1 (NRG-1), which is a member of the NRG gene family, acts as a paracrine factor in dendritic cells and is involved in tumor immunity 30 .…”

Section: Discussionmentioning

confidence: 99%

Significance of Immune-related Genes in the Diagnosis and Subtype Classification of Childhood Asthma

Dai

Sun

Cai

et al. 2020

Preprint

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Background Childhood asthma is one of the most common causes of hospitalization in children, causing huge economic losses worldwide. The immune system was closely linked to the occurrence and development of childhood asthma. The main purpose of this research is to explore the role of immune-related genes in the occurrence and treatment of childhood asthma.Methods GSE40732 dataset and GSE40888 dataset were respectively regarded as training dataset and texting dataset in this article. We performed weighted gene co-expression network analysis (WGCNA) to select immune-related genes associated with the occurrence of childhood asthma based on the training dataset. Random forest (RF) model was established to screen the optimal variables to predict the occurrence of childhood asthma among these significant immune-related genes. Childhood asthma patients were grouped by the consensus clustering method based on the optimal variables. The grouping results were validated in the texting dataset. Results 69 significant immune-related genes associated with the occurrence of childhood asthma were screened through WGCNA. RF model indicated that 10 optimal variables among these significant immune-related genes can reasonably distinguish normal children and childhood asthma. Childhood asthma patients were classified into two molecular subtypes (Sub1 and Sub2) based on the 10 optimal variables using consensus clustering analysis. More interestingly, childhood asthma patients in Sub1 have higher inflammatory response than Sub2.Conclusions Our research selected 10 significant immune-related genes related to the occurrence of childhood asthma. We classified childhood asthma patients into two molecular subtypes with different immune cell infiltration based on the 10 significant immune-related genes, which may provide the basis for individualized treatment.

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Section: Discussionmentioning

confidence: 99%

Significance of Immune-related Genes in the Diagnosis and Subtype Classification of Childhood Asthma

Dai

Sun

Cai

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…The structural characteristics of the encoded proteins of the CMTM family have similarities with those of chemokines and transmembrane-4 superfamily (TM4SF) members. Previous research showed that CMTM family members may have involvement in the progression of autoimmune (2) and cardiovascular diseases (3). Besides, mounting studies have pointed toward CMTM family members being pivotal players in tumor-related biological processes (BP).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of the prognostic value of the chemokine-like factor-like MARVEL transmembrane domain-containing family in gastric cancer

Liang¹,

Xie²,

Huang³

et al. 2021

J Gastrointest Oncol

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Background: The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing (CMTM) family refers to a family of transcriptional repressor genes. CMTMs are closely associated with the epigenetic regulatory mechanisms and development of multiple malignancies, including gastric cancer. However, their specific biological functions and prognostic values in gastric cancer have yet to be elucidated.Methods: Tumor sample datasets were retrieved and analyzed using databases including Oncomine, STRING, GEPIA2, cBioportal, and Kaplan-Meier plotter. To investigate the prognostic role of CMTMs in gastric cancer, we applied unsupervised hierarchical clustering analysis of CMTM gene expression patterns.Results: While the mRNA levels of CMTM1/3/6/7/8 were upregulated in gastric cancer, CMTM2/4/5 showed no statistically significant difference at the mRNA level in patients with gastric cancer. Moreover, the mRNA expressions of different CMTMs exhibited strong correlations with various clinical parameters of patients with gastric cancer, including tumor stage, metastatic lymph node status, H. pylori status, and tumor grade. Also, the results suggested that elevated levels of CMTM3/5 mRNA had a significant association (P<0.05) with poor overall survival, progression-free survival, and post-progression survival. Conversely, elevated expression of CMTM2/4/6 mRNA had a significant association with better overall survival, progression-free survival, and post-progression survival. Unsupervised hierarchical clustering analysis successfully identified 2 major clusters of patients as follows: signature #1: CMTM4/6/8 and signature #2: CMTM1/2/3/5/7. Signature #2 was closely correlated with poorer overall survival, which indicated that the expression pattern of the CMTM family could be a novel prognostic factor for patients with gastric cancer.Conclusions: These results suggest that the expression levels of CMTM genes possibly have prognostic value as a biomarker of gastric cancer.

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“…The CMTM family was first cloned and reported in 2001 1 . To date, CMTM family members have been revealed to function as regulators in various diseases, including autoimmune 2 and cardiovascular diseases 3 . Moreover, recent in-depth studies have indicated that CMTMs also play crucial roles in cancer-associated biological regulation.…”

Section: Introductionmentioning

confidence: 99%

CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value

et al. 2020

Cancer Biol. Med.

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Chemokine-like factor-like MARVEL transmembrane domain-containing family in autoimmune diseases

Cited by 29 publications

References 82 publications

Significance of Immune-related Genes in the Diagnosis and Subtype Classification of Childhood Asthma

Significance of Immune-related Genes in the Diagnosis and Subtype Classification of Childhood Asthma

Comprehensive analysis of the prognostic value of the chemokine-like factor-like MARVEL transmembrane domain-containing family in gastric cancer

CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value

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