Chemokine-mobilized adult stem cells; defining a better hematopoietic graft

Pelus, Louis M.; Fukuda, Seiji

doi:10.1038/sj.leu.2405021

Cited by 63 publications

(46 citation statements)

References 105 publications

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“…27,49,50 Mobilization could also be induced within hours after administration of certain chemokines (for example, interleukin-8, growth-related oncogene protein-beta (Gro-b) or macrophage inhibitory protein-1a), multiple injection of certain growth factors (for example, Fms-like tyrosine kinase 3, kit ligand or vascular endothelial growth factor), small-molecule antagonists of the CXCR4 receptor (for example, AMD3100 or T139) or a small-molecule antagonist of VLA-4 (BIO4860). [51][52][53][54][55][56][57][58][59][60][61][62][63][64][65] To obtain more efficient and faster mobilization, some of these compounds could be administered together (for example, G-CSF with AMD3100 or growth-related oncogene protein-beta with AMD3100). 28,61 Mobilization could also be achieved by the administration of some types of polysaccharides (for example, zymosan or fucoidans) that in animal models have been demonstrated to efficiently mobilize HSPCs within 1 h after a single injection.…”

Section: Pharmacological Mobilization Of Hspcsmentioning

confidence: 99%

Innate immunity as orchestrator of stem cell mobilization

et al. 2010

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Section: Pharmacological Mobilization Of Hspcsmentioning

confidence: 99%

Innate immunity as orchestrator of stem cell mobilization

et al. 2010

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“…In the clinical setting, granulocyte colony-stimulating factor (G-CSF) is the most commonly used inducer of HSPC mobilization, which has become the preferred source of HSPC for autologous and allogeneic hematopoietic reconstitution. 2,3 Although it is effective and safe, G-CSF mobilizes committed myeloid cells in vast excess of HSPC, and these cells are mobilized only after 5 to 7 days of treatment. 4 Thus, a better understanding of the mechanisms of action of G-CSF could provide a means to pursue a more selective and rapid mobilization of HSPC.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1

Salvucci

Jiang²,

Gasperini³

et al. 2012

Haematologica

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The online version of this article has a Supplementary Appendix. BackgroundMobilization of hematopoietic stem/progenitor cells from the bone marrow to the peripheral blood by granulocyte colony-stimulating factor is the primary means to acquire stem cell grafts for hematopoietic cell transplantation. Since hematopoietic stem/progenitor cells represent a minority of all blood cells mobilized by granulocyte colony-stimulating factor, the underlying mechanisms need to be understood in order to develop selective drugs. Design and MethodsWe analyzed phenotypic, biochemical and genetic changes in bone marrow cell populations from granulocyte colony-stimulating factor-mobilized and control mice, and linked such changes to effective mobilization of hematopoietic stem/progenitor cells. ResultsWe show that granulocyte colony-stimulating factor indirectly reduces expression of surface vascular cell adhesion molecule 1 on bone marrow hematopoietic stem/progenitor cells, stromal cells and endothelial cells by promoting the accumulation of microRNA-126 (miR126)-containing microvescicles in the bone marrow extracellular compartment. We found that hematopoietic stem/progenitor cells, stromal cells and endothelial cells readily incorporate these miR126-loaded microvescicles, and that miR126 represses vascular cell adhesion molecule 1 expression on bone marrow hematopoietic stem/progenitor cells, stromal cells and endothelial cells. In line with this, miR126-null mice displayed a reduced mobilization response to granulocyte colony-stimulating factor. ConclusionsOur results implicate miR126 in the regulation of hematopoietic stem/progenitor cell trafficking between the bone marrow and peripheral sites, clarify the role of vascular cell adhesion molecule 1 in granulocyte colony-stimulating factor-mediated mobilization, and have important implications for improved approaches to selective mobilization of hematopoietic stem/progenitor cells.

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“…Eukaryotic cells migrate in the body along external chemotactic gradients [1,41,42] . Chemotactic stimuli are sensed by heterotrimeric G-protein coupled receptors, the main class of which is the chemokine receptors [43] .…”

Section: Candidate Molecular Pathways Responsible For Migration Of Mementioning

confidence: 99%

Adipose Tissue-Derived Progenitor Cells and Cancer

Tseng¹,

Kolonin²

2013

Angiogenesis in Adipose Tissue

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Recruitment of stem cells and partially differentiated progenitor cells is a process which accompanies and facilitates the progression of cancer. One of the factors complicating the clinical course of cancer is obesity, a progressively widespread medical condition resulting from overgrowth of white adipose tissue (WAT), commonly known as white fat. The mechanisms by which obesity influences cancer risk and progression are not completely understood. Cells of WAT secret soluble molecules (adipokines) that could stimulate tumor growth, although there is no consensus on which cell populations and which adipokines are important. Recent reports suggest that WAT-derived mesenchymal stem (stromal) cells, termed adipose stem cells (ASC), may represent a cell population linking obesity and cancer.Studies in animal models demonstrate that adipokines secreted by ASC can promote tumor growth by assisting in formation of new blood vessels, a process necessary for expansion of tumor mass. Importantly, migration of ASC from WAT to tumors has been demonstrated, indicating that the tumor microenvironment in cancer may be modulated by ASC-derived trophic factors in a paracrine rather than in an endocrine manner. Here, we review possible positive and adverse implications of progenitor cell recruitment into the diseased sites with a particular emphasis on the role in cancer progression of progenitors that are expanded in obesity.

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Chemokine-mobilized adult stem cells; defining a better hematopoietic graft

Cited by 63 publications

References 105 publications

Innate immunity as orchestrator of stem cell mobilization

Innate immunity as orchestrator of stem cell mobilization

MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1

Adipose Tissue-Derived Progenitor Cells and Cancer

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